Joule heating in the electromagnetic cell sorting system is problematic. Our micro-device was fabricated for the rapid separation by high magnetic field gradients of electromagnet and dissipates the Joule heat energy that causes unnecessary heat-up in the device. By using a cooling channel embedded in microfluidic channel, Joule heat can be reduced to dissipate thermal energy to an active area of a microfluidic channel and maintain the temperature of device biocompatible, e.g. 37 °C. We analyzed the temperature distribution of the device using numerical model and compared with the experimental data. Finally, we demonstrated the magnetic beads separation and obtained the separation efficiency of 97%.
Bibliographical noteFunding Information:
This work was supported by National Core Research Center (NCRC) for Nanomedical Technology from the Korea Science & Engineering Foundation (Grant No. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 10816), in part by the Grant (20070501-034-006-009-03-00) from BioGreen21 Program, Rural Development Administration, Republic of Korea.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Physics and Astronomy(all)