Analysis and utilization of Joule heating in an electromagnet integrated microfluidic device for biological applications

Suk Heung Song; Bong Seop Kwak; Hyo Il Jung

doi:10.1016/j.cap.2009.06.023

Analysis and utilization of Joule heating in an electromagnet integrated microfluidic device for biological applications

Suk Heung Song, Bong Seop Kwak, Hyo Il Jung

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Joule heating in the electromagnetic cell sorting system is problematic. Our micro-device was fabricated for the rapid separation by high magnetic field gradients of electromagnet and dissipates the Joule heat energy that causes unnecessary heat-up in the device. By using a cooling channel embedded in microfluidic channel, Joule heat can be reduced to dissipate thermal energy to an active area of a microfluidic channel and maintain the temperature of device biocompatible, e.g. 37 °C. We analyzed the temperature distribution of the device using numerical model and compared with the experimental data. Finally, we demonstrated the magnetic beads separation and obtained the separation efficiency of 97%.

Original language	English
Pages (from-to)	e287-e290
Journal	Current Applied Physics
Volume	9
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.cap.2009.06.023
Publication status	Published - 2009 Jul

Bibliographical note

Funding Information:
This work was supported by National Core Research Center (NCRC) for Nanomedical Technology from the Korea Science & Engineering Foundation (Grant No. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 10816), in part by the Grant (20070501-034-006-009-03-00) from BioGreen21 Program, Rural Development Administration, Republic of Korea.

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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title = "Analysis and utilization of Joule heating in an electromagnet integrated microfluidic device for biological applications",

abstract = "Joule heating in the electromagnetic cell sorting system is problematic. Our micro-device was fabricated for the rapid separation by high magnetic field gradients of electromagnet and dissipates the Joule heat energy that causes unnecessary heat-up in the device. By using a cooling channel embedded in microfluidic channel, Joule heat can be reduced to dissipate thermal energy to an active area of a microfluidic channel and maintain the temperature of device biocompatible, e.g. 37 °C. We analyzed the temperature distribution of the device using numerical model and compared with the experimental data. Finally, we demonstrated the magnetic beads separation and obtained the separation efficiency of 97%.",

author = "Song, {Suk Heung} and Kwak, {Bong Seop} and Jung, {Hyo Il}",

note = "Funding Information: This work was supported by National Core Research Center (NCRC) for Nanomedical Technology from the Korea Science & Engineering Foundation (Grant No. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 10816), in part by the Grant (20070501-034-006-009-03-00) from BioGreen21 Program, Rural Development Administration, Republic of Korea.",

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AU - Song, Suk Heung

AU - Kwak, Bong Seop

AU - Jung, Hyo Il

N1 - Funding Information: This work was supported by National Core Research Center (NCRC) for Nanomedical Technology from the Korea Science & Engineering Foundation (Grant No. R15-2004-024-01001-0), Seoul Research & Business Development (Seoul R&BD Program, 10816), in part by the Grant (20070501-034-006-009-03-00) from BioGreen21 Program, Rural Development Administration, Republic of Korea.

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N2 - Joule heating in the electromagnetic cell sorting system is problematic. Our micro-device was fabricated for the rapid separation by high magnetic field gradients of electromagnet and dissipates the Joule heat energy that causes unnecessary heat-up in the device. By using a cooling channel embedded in microfluidic channel, Joule heat can be reduced to dissipate thermal energy to an active area of a microfluidic channel and maintain the temperature of device biocompatible, e.g. 37 °C. We analyzed the temperature distribution of the device using numerical model and compared with the experimental data. Finally, we demonstrated the magnetic beads separation and obtained the separation efficiency of 97%.

AB - Joule heating in the electromagnetic cell sorting system is problematic. Our micro-device was fabricated for the rapid separation by high magnetic field gradients of electromagnet and dissipates the Joule heat energy that causes unnecessary heat-up in the device. By using a cooling channel embedded in microfluidic channel, Joule heat can be reduced to dissipate thermal energy to an active area of a microfluidic channel and maintain the temperature of device biocompatible, e.g. 37 °C. We analyzed the temperature distribution of the device using numerical model and compared with the experimental data. Finally, we demonstrated the magnetic beads separation and obtained the separation efficiency of 97%.

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Analysis and utilization of Joule heating in an electromagnet integrated microfluidic device for biological applications

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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