Analysis of clinical outcomes of patients with adenoid cystic carcinoma of Bartholin glands

Gun Yoon, Hyunsoo Kim, Yoo Young Lee, Tae Joong Kim, Chel Hun Choi, Sang Yong Song, Byoung Gie Kim, Duk Soo Bae, Jeong Won Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Adenoid cystic carcinoma of Bartholin glands (BG-ACC) is a rare, slow-growing but a highly aggressive tumor with remarkable capacity for local recurrence and distant metastasis. The purpose of this study was to elucidate our experiences of the diagnosis and treatment of BG-ACC and to analyze the clinical outcomes and prognosis of patients with BG-ACC. A retrospective chart review was performed to assess the demographic information, chief complaints, pathologic features of tumors, primary treatment, and development of local recurrence or distant metastasis, as well as the patient outcome. All patients received surgical excision as the primary treatment, and the diagnosis of BG-ACC was confirmed histopathologically. Three of four patients whose tumors showed pathologic features indicating a high probability of recurrence received adjuvant radiotherapy. These patients did not develop local recurrence, in contrast, one patient who did not receive adjuvant radiotherapy developed local recurrence and distant metastasis on several occasions. All patients who received primary surgical treatment are alive to date. When patients who are more than 40 years of age and who present with symptomatic BG lesions, BG-ACC should be included in the differential diagnosis and biopsy should be performed for histopathologic confirmation. Radical local excision with sufficient negative margins seems to be beneficial for primary treatment. Adjuvant radiotherapy is a reasonable treatment option for patients with high risk factors after surgery or for patients who develop local recurrence.

Original languageEnglish
Pages (from-to)5688-5694
Number of pages7
JournalInternational Journal of Clinical and Experimental Pathology
Volume8
Issue number5
Publication statusPublished - 2015 Jan 1

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Bartholin's Glands
Adenoid Cystic Carcinoma
Recurrence
Adjuvant Radiotherapy
Neoplasm Metastasis
Therapeutics
Neoplasms
Differential Diagnosis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Yoon, Gun ; Kim, Hyunsoo ; Lee, Yoo Young ; Kim, Tae Joong ; Choi, Chel Hun ; Song, Sang Yong ; Kim, Byoung Gie ; Bae, Duk Soo ; Lee, Jeong Won. / Analysis of clinical outcomes of patients with adenoid cystic carcinoma of Bartholin glands. In: International Journal of Clinical and Experimental Pathology. 2015 ; Vol. 8, No. 5. pp. 5688-5694.
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abstract = "Adenoid cystic carcinoma of Bartholin glands (BG-ACC) is a rare, slow-growing but a highly aggressive tumor with remarkable capacity for local recurrence and distant metastasis. The purpose of this study was to elucidate our experiences of the diagnosis and treatment of BG-ACC and to analyze the clinical outcomes and prognosis of patients with BG-ACC. A retrospective chart review was performed to assess the demographic information, chief complaints, pathologic features of tumors, primary treatment, and development of local recurrence or distant metastasis, as well as the patient outcome. All patients received surgical excision as the primary treatment, and the diagnosis of BG-ACC was confirmed histopathologically. Three of four patients whose tumors showed pathologic features indicating a high probability of recurrence received adjuvant radiotherapy. These patients did not develop local recurrence, in contrast, one patient who did not receive adjuvant radiotherapy developed local recurrence and distant metastasis on several occasions. All patients who received primary surgical treatment are alive to date. When patients who are more than 40 years of age and who present with symptomatic BG lesions, BG-ACC should be included in the differential diagnosis and biopsy should be performed for histopathologic confirmation. Radical local excision with sufficient negative margins seems to be beneficial for primary treatment. Adjuvant radiotherapy is a reasonable treatment option for patients with high risk factors after surgery or for patients who develop local recurrence.",
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Yoon, G, Kim, H, Lee, YY, Kim, TJ, Choi, CH, Song, SY, Kim, BG, Bae, DS & Lee, JW 2015, 'Analysis of clinical outcomes of patients with adenoid cystic carcinoma of Bartholin glands', International Journal of Clinical and Experimental Pathology, vol. 8, no. 5, pp. 5688-5694.

Analysis of clinical outcomes of patients with adenoid cystic carcinoma of Bartholin glands. / Yoon, Gun; Kim, Hyunsoo; Lee, Yoo Young; Kim, Tae Joong; Choi, Chel Hun; Song, Sang Yong; Kim, Byoung Gie; Bae, Duk Soo; Lee, Jeong Won.

In: International Journal of Clinical and Experimental Pathology, Vol. 8, No. 5, 01.01.2015, p. 5688-5694.

Research output: Contribution to journalArticle

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