Analysis of curvature effects on plasmon biosensing of molecular interactions

Hyunwoong Lee, Donghyun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Surface plasmon represents oscillations of electrons at the interface between metal and dielectric layers. Surface plasmon resonance (SPR) is influenced by the environment near the surface, which has been the basis for label-free biosensor structure for various applications of molecular detection. An important aspect of SPR biosensing is that its characteristics are affected by the geometrical structure. Yet most research has focused largely on a structure using flat surface. Although flat structure is suitable for typical sensor applications, it may not be appropriate for wearable or in vivo applications. In this study, we analyzed the effects of surface curvature on flexible SPR biosensors. Curved surface was approximated using a segmented model in which each segment is treated as a flat surface with a different incident angle and then optical characteristics of the overall model were calculated by rigorous coupled wave analysis in two different configurations of light incidence. We calculated curvature effects on SPR with curvature radius larger than 255 μm. It was found that regardless of the incident configurations, resonance curves tend to broaden with increased curvature due to larger momentum dispersion. Resonance shifts as a result of DNA immobilization and hybridization decrease with curvature. The analysis was extended to multi-curvature structure and finds significant fluctuation of resonance shift for parallel light incidence. The study can be of profound importance for plasmonic devices using flexible substrates.

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine XIV
EditorsTuan Vo-Dinh, Joseph R. Lakowicz
PublisherSPIE
Volume10080
ISBN (Electronic)9781510606012
DOIs
Publication statusPublished - 2017 Jan 1
EventPlasmonics in Biology and Medicine XIV - San Francisco, United States
Duration: 2017 Jan 30 → …

Other

OtherPlasmonics in Biology and Medicine XIV
CountryUnited States
CitySan Francisco
Period17/1/30 → …

Fingerprint

Surface Plasmon Resonance
Molecular interactions
molecular interactions
curvature
Surface plasmon resonance
surface plasmon resonance
Biosensing Techniques
bioinstrumentation
Light
Biosensors
flat surfaces
Incidence
incidence
Immobilization
curved surfaces
Metals
shift
Electrons
configurations
immobilization

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Lee, H., & Kim, D. (2017). Analysis of curvature effects on plasmon biosensing of molecular interactions. In T. Vo-Dinh, & J. R. Lakowicz (Eds.), Plasmonics in Biology and Medicine XIV (Vol. 10080). [100800O] SPIE. https://doi.org/10.1117/12.2250684
Lee, Hyunwoong ; Kim, Donghyun. / Analysis of curvature effects on plasmon biosensing of molecular interactions. Plasmonics in Biology and Medicine XIV. editor / Tuan Vo-Dinh ; Joseph R. Lakowicz. Vol. 10080 SPIE, 2017.
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Lee, H & Kim, D 2017, Analysis of curvature effects on plasmon biosensing of molecular interactions. in T Vo-Dinh & JR Lakowicz (eds), Plasmonics in Biology and Medicine XIV. vol. 10080, 100800O, SPIE, Plasmonics in Biology and Medicine XIV, San Francisco, United States, 17/1/30. https://doi.org/10.1117/12.2250684

Analysis of curvature effects on plasmon biosensing of molecular interactions. / Lee, Hyunwoong; Kim, Donghyun.

Plasmonics in Biology and Medicine XIV. ed. / Tuan Vo-Dinh; Joseph R. Lakowicz. Vol. 10080 SPIE, 2017. 100800O.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lee H, Kim D. Analysis of curvature effects on plasmon biosensing of molecular interactions. In Vo-Dinh T, Lakowicz JR, editors, Plasmonics in Biology and Medicine XIV. Vol. 10080. SPIE. 2017. 100800O https://doi.org/10.1117/12.2250684