Lake Enriquillo is the largest lake in the Dominican Republic. It is one of only a few saltwater lakes in the world. The lake ecosystem shows the unique species of iguana the "Ricord", and is a habitat for many kinds of birds, animals and plants and a large range of others. The Lake Enriquillo covers an area of 265 km 2 and water level varies because of a combination of storm and high evaporation rate. In the present study, we examined the Characteristic of lake water body difference in the Enriquillo using 2 Landsat Enhanced Thematic Mapper Plus (ETM+) imageries over a 6 years period. The Normalized Difference Vegetation Index (NDVI) and Modified Normalized Difference Water Index (MNDWI) methods were used to detect changed lake water body and bare soil ground cover. The result shows that remote sensing data can provide efficient information to support the lake ecosystem management.