Analysis of prognostic factors in patients with multiple recurrences of papillary thyroid carcinoma

Kwang Min Kim, Joon Beom Park, Keum Seok Bae, Seong Joon Kang

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Purpose: Numerous studies in the past have mentioned various factors that influence the recurrence of papillary thyroid carcinoma, including age, tumor size, advanced stage, extrathyroidal extension, and distant metastasis, and attempts have been made to classify the disease into low-risk and high-risk group based on these clinicopathological factors. However, there has been relatively scarce study on patients with multiple recurrent papillary thyroid carcinoma. This study analyzed the risk factors associated with such cases. Materials and methods: This study investigated various clinicopathological factors of 416 patients who were diagnosed with papillary thyroid carcinoma and received primary surgery at Yonsei University Wonju College of Medicine, Department of Surgery, from January 1983 to December 2006 and were followed up until October 2010. An investigation of factors associated with patients showing multiple recurrences was made. Results: Patients were divided into 3 groups: group 1 (no recurrence, n = 380), group 2 (1 recurrence only, n = 21), and group 3 (multiple recurrences, n = 15). The univariate analysis on risk factors revealed tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis to be risk factors associated with multiple recurrences of papillary thyroid carcinoma. A multivariate analysis performed on variables selected from univariate analysis demonstrated no significant risk factor. The 10-year disease-specific survival for 3 different patient groups (group 1, 2, and 3) was 100%, 100%, and 83.1%, respectively, and patients in more clinically advanced group demonstrated poorer prognosis (p < 0.001). The 10-year overall survival rate for the 3 patient groups was 93.9%, 100%, and 92%, respectively, and clinically advanced groups tended to show poorer overall survival rate as well (p = 0.046). Discussion: A more aggressive and extensive surgery, as well as closer follow up, is to be required when operating on patients with tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis. The use of imaging modalities, such as ultrasonography and PET-CT scan, may be desirable when monitoring such patients.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalSurgical Oncology
Volume21
Issue number3
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Recurrence
Neoplasm Metastasis
Survival Rate
Lymph Nodes
Neoplasms
Papillary Thyroid cancer
Physiologic Monitoring
Ultrasonography
Multivariate Analysis
Medicine
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Kwang Min ; Park, Joon Beom ; Bae, Keum Seok ; Kang, Seong Joon. / Analysis of prognostic factors in patients with multiple recurrences of papillary thyroid carcinoma. In: Surgical Oncology. 2012 ; Vol. 21, No. 3. pp. 185-190.
@article{6b49508addb3439794ffd152896f92d9,
title = "Analysis of prognostic factors in patients with multiple recurrences of papillary thyroid carcinoma",
abstract = "Purpose: Numerous studies in the past have mentioned various factors that influence the recurrence of papillary thyroid carcinoma, including age, tumor size, advanced stage, extrathyroidal extension, and distant metastasis, and attempts have been made to classify the disease into low-risk and high-risk group based on these clinicopathological factors. However, there has been relatively scarce study on patients with multiple recurrent papillary thyroid carcinoma. This study analyzed the risk factors associated with such cases. Materials and methods: This study investigated various clinicopathological factors of 416 patients who were diagnosed with papillary thyroid carcinoma and received primary surgery at Yonsei University Wonju College of Medicine, Department of Surgery, from January 1983 to December 2006 and were followed up until October 2010. An investigation of factors associated with patients showing multiple recurrences was made. Results: Patients were divided into 3 groups: group 1 (no recurrence, n = 380), group 2 (1 recurrence only, n = 21), and group 3 (multiple recurrences, n = 15). The univariate analysis on risk factors revealed tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis to be risk factors associated with multiple recurrences of papillary thyroid carcinoma. A multivariate analysis performed on variables selected from univariate analysis demonstrated no significant risk factor. The 10-year disease-specific survival for 3 different patient groups (group 1, 2, and 3) was 100{\%}, 100{\%}, and 83.1{\%}, respectively, and patients in more clinically advanced group demonstrated poorer prognosis (p < 0.001). The 10-year overall survival rate for the 3 patient groups was 93.9{\%}, 100{\%}, and 92{\%}, respectively, and clinically advanced groups tended to show poorer overall survival rate as well (p = 0.046). Discussion: A more aggressive and extensive surgery, as well as closer follow up, is to be required when operating on patients with tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis. The use of imaging modalities, such as ultrasonography and PET-CT scan, may be desirable when monitoring such patients.",
author = "Kim, {Kwang Min} and Park, {Joon Beom} and Bae, {Keum Seok} and Kang, {Seong Joon}",
year = "2012",
month = "9",
day = "1",
doi = "10.1016/j.suronc.2011.07.004",
language = "English",
volume = "21",
pages = "185--190",
journal = "Surgical Oncology",
issn = "0960-7404",
publisher = "Elsevier BV",
number = "3",

}

Analysis of prognostic factors in patients with multiple recurrences of papillary thyroid carcinoma. / Kim, Kwang Min; Park, Joon Beom; Bae, Keum Seok; Kang, Seong Joon.

In: Surgical Oncology, Vol. 21, No. 3, 01.09.2012, p. 185-190.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Analysis of prognostic factors in patients with multiple recurrences of papillary thyroid carcinoma

AU - Kim, Kwang Min

AU - Park, Joon Beom

AU - Bae, Keum Seok

AU - Kang, Seong Joon

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Purpose: Numerous studies in the past have mentioned various factors that influence the recurrence of papillary thyroid carcinoma, including age, tumor size, advanced stage, extrathyroidal extension, and distant metastasis, and attempts have been made to classify the disease into low-risk and high-risk group based on these clinicopathological factors. However, there has been relatively scarce study on patients with multiple recurrent papillary thyroid carcinoma. This study analyzed the risk factors associated with such cases. Materials and methods: This study investigated various clinicopathological factors of 416 patients who were diagnosed with papillary thyroid carcinoma and received primary surgery at Yonsei University Wonju College of Medicine, Department of Surgery, from January 1983 to December 2006 and were followed up until October 2010. An investigation of factors associated with patients showing multiple recurrences was made. Results: Patients were divided into 3 groups: group 1 (no recurrence, n = 380), group 2 (1 recurrence only, n = 21), and group 3 (multiple recurrences, n = 15). The univariate analysis on risk factors revealed tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis to be risk factors associated with multiple recurrences of papillary thyroid carcinoma. A multivariate analysis performed on variables selected from univariate analysis demonstrated no significant risk factor. The 10-year disease-specific survival for 3 different patient groups (group 1, 2, and 3) was 100%, 100%, and 83.1%, respectively, and patients in more clinically advanced group demonstrated poorer prognosis (p < 0.001). The 10-year overall survival rate for the 3 patient groups was 93.9%, 100%, and 92%, respectively, and clinically advanced groups tended to show poorer overall survival rate as well (p = 0.046). Discussion: A more aggressive and extensive surgery, as well as closer follow up, is to be required when operating on patients with tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis. The use of imaging modalities, such as ultrasonography and PET-CT scan, may be desirable when monitoring such patients.

AB - Purpose: Numerous studies in the past have mentioned various factors that influence the recurrence of papillary thyroid carcinoma, including age, tumor size, advanced stage, extrathyroidal extension, and distant metastasis, and attempts have been made to classify the disease into low-risk and high-risk group based on these clinicopathological factors. However, there has been relatively scarce study on patients with multiple recurrent papillary thyroid carcinoma. This study analyzed the risk factors associated with such cases. Materials and methods: This study investigated various clinicopathological factors of 416 patients who were diagnosed with papillary thyroid carcinoma and received primary surgery at Yonsei University Wonju College of Medicine, Department of Surgery, from January 1983 to December 2006 and were followed up until October 2010. An investigation of factors associated with patients showing multiple recurrences was made. Results: Patients were divided into 3 groups: group 1 (no recurrence, n = 380), group 2 (1 recurrence only, n = 21), and group 3 (multiple recurrences, n = 15). The univariate analysis on risk factors revealed tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis to be risk factors associated with multiple recurrences of papillary thyroid carcinoma. A multivariate analysis performed on variables selected from univariate analysis demonstrated no significant risk factor. The 10-year disease-specific survival for 3 different patient groups (group 1, 2, and 3) was 100%, 100%, and 83.1%, respectively, and patients in more clinically advanced group demonstrated poorer prognosis (p < 0.001). The 10-year overall survival rate for the 3 patient groups was 93.9%, 100%, and 92%, respectively, and clinically advanced groups tended to show poorer overall survival rate as well (p = 0.046). Discussion: A more aggressive and extensive surgery, as well as closer follow up, is to be required when operating on patients with tumor size greater than 2 cm, multifocality, clinical apparent lymph node metastasis. The use of imaging modalities, such as ultrasonography and PET-CT scan, may be desirable when monitoring such patients.

UR - http://www.scopus.com/inward/record.url?scp=84864677698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864677698&partnerID=8YFLogxK

U2 - 10.1016/j.suronc.2011.07.004

DO - 10.1016/j.suronc.2011.07.004

M3 - Review article

C2 - 21855321

AN - SCOPUS:84864677698

VL - 21

SP - 185

EP - 190

JO - Surgical Oncology

JF - Surgical Oncology

SN - 0960-7404

IS - 3

ER -