Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

Hannah Seok, Eun Young Lee, Eun Yeong Choe, Woo In Yang, Joo Young Kim, Dong Yeob Shin, Ho Jin Cho, Tae Sung Kim, Mi Jin Yun, Jong Doo Lee, Eun Jig Lee, Sung Kil Lim, Yumie Rhee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18Ffluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalKorean Journal of Internal Medicine
Volume28
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Magnetic Resonance Imaging
Pituitary Neoplasms
Adenoma
Pituitary Gland
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Seok, Hannah ; Lee, Eun Young ; Choe, Eun Yeong ; Yang, Woo In ; Kim, Joo Young ; Shin, Dong Yeob ; Cho, Ho Jin ; Kim, Tae Sung ; Yun, Mi Jin ; Lee, Jong Doo ; Lee, Eun Jig ; Lim, Sung Kil ; Rhee, Yumie. / Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions. In: Korean Journal of Internal Medicine. 2013 ; Vol. 28, No. 1. pp. 81-88.
@article{8463c1088f534fcf981560861abfe857,
title = "Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions",
abstract = "Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18Ffluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2{\%}) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50{\%}) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7{\%} sensitivity and 100{\%} specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80{\%} of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.",
author = "Hannah Seok and Lee, {Eun Young} and Choe, {Eun Yeong} and Yang, {Woo In} and Kim, {Joo Young} and Shin, {Dong Yeob} and Cho, {Ho Jin} and Kim, {Tae Sung} and Yun, {Mi Jin} and Lee, {Jong Doo} and Lee, {Eun Jig} and Lim, {Sung Kil} and Yumie Rhee",
year = "2013",
month = "1",
day = "1",
doi = "10.3904/kjim.2013.28.1.81",
language = "English",
volume = "28",
pages = "81--88",
journal = "Korean Journal of Internal Medicine",
issn = "1226-3303",
publisher = "Korean Association of Internal Medicine",
number = "1",

}

Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions. / Seok, Hannah; Lee, Eun Young; Choe, Eun Yeong; Yang, Woo In; Kim, Joo Young; Shin, Dong Yeob; Cho, Ho Jin; Kim, Tae Sung; Yun, Mi Jin; Lee, Jong Doo; Lee, Eun Jig; Lim, Sung Kil; Rhee, Yumie.

In: Korean Journal of Internal Medicine, Vol. 28, No. 1, 01.01.2013, p. 81-88.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

AU - Seok, Hannah

AU - Lee, Eun Young

AU - Choe, Eun Yeong

AU - Yang, Woo In

AU - Kim, Joo Young

AU - Shin, Dong Yeob

AU - Cho, Ho Jin

AU - Kim, Tae Sung

AU - Yun, Mi Jin

AU - Lee, Jong Doo

AU - Lee, Eun Jig

AU - Lim, Sung Kil

AU - Rhee, Yumie

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18Ffluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.

AB - Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18Ffluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.

UR - http://www.scopus.com/inward/record.url?scp=84873845481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873845481&partnerID=8YFLogxK

U2 - 10.3904/kjim.2013.28.1.81

DO - 10.3904/kjim.2013.28.1.81

M3 - Article

C2 - 23346000

AN - SCOPUS:84873845481

VL - 28

SP - 81

EP - 88

JO - Korean Journal of Internal Medicine

JF - Korean Journal of Internal Medicine

SN - 1226-3303

IS - 1

ER -