Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients

Sang Yeop Lee, Soo Jung Han, Sang Min Nam, Sang Chul Yoon, Ji Min Ahn, Tae-im Kim, Eungkweon Kim, KyoungYul Seo

Research output: Contribution to journalArticle

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Abstract

Purpose: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design: Prospective cross-sectional study. Methods: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P <.001, non-SS > control P =.042, SS > non-SS P <.001; TNF-α: SS > control P =.006, non-SS > control P =.034, SS > non-SS P =.029; IL-6: SS > control P =.002, non-SS > control P =.032, SS > non-SS P =.002). IL-17 was significantly correlated with TBUT (R = -0.22, P =.012) and Schirmer I test (R = -0.36, P =.027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P =.02) in the non-SS group. Conclusions: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume156
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

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Dry Eye Syndromes
Tears
Cytokines
Interleukin-17
Interleukin-6
Interleukin-2
Eye Diseases

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

@article{100e5078cde44eca884d81ae3b345b53,
title = "Analysis of tear cytokines and clinical correlations in Sj{\"o}gren syndrome dry eye patients and non-Sj{\"o}gren syndrome dry eye patients",
abstract = "Purpose: To compare concentrations of tear cytokines in 3 groups composed of Sj{\"o}gren syndrome (SS) dry eye, non-Sj{\"o}gren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design: Prospective cross-sectional study. Methods: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P <.001, non-SS > control P =.042, SS > non-SS P <.001; TNF-α: SS > control P =.006, non-SS > control P =.034, SS > non-SS P =.029; IL-6: SS > control P =.002, non-SS > control P =.032, SS > non-SS P =.002). IL-17 was significantly correlated with TBUT (R = -0.22, P =.012) and Schirmer I test (R = -0.36, P =.027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P =.02) in the non-SS group. Conclusions: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.",
author = "Lee, {Sang Yeop} and Han, {Soo Jung} and Nam, {Sang Min} and Yoon, {Sang Chul} and Ahn, {Ji Min} and Tae-im Kim and Eungkweon Kim and KyoungYul Seo",
year = "2013",
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language = "English",
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Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients. / Lee, Sang Yeop; Han, Soo Jung; Nam, Sang Min; Yoon, Sang Chul; Ahn, Ji Min; Kim, Tae-im; Kim, Eungkweon; Seo, KyoungYul.

In: American Journal of Ophthalmology, Vol. 156, No. 2, 01.01.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients

AU - Lee, Sang Yeop

AU - Han, Soo Jung

AU - Nam, Sang Min

AU - Yoon, Sang Chul

AU - Ahn, Ji Min

AU - Kim, Tae-im

AU - Kim, Eungkweon

AU - Seo, KyoungYul

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design: Prospective cross-sectional study. Methods: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P <.001, non-SS > control P =.042, SS > non-SS P <.001; TNF-α: SS > control P =.006, non-SS > control P =.034, SS > non-SS P =.029; IL-6: SS > control P =.002, non-SS > control P =.032, SS > non-SS P =.002). IL-17 was significantly correlated with TBUT (R = -0.22, P =.012) and Schirmer I test (R = -0.36, P =.027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P =.02) in the non-SS group. Conclusions: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.

AB - Purpose: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design: Prospective cross-sectional study. Methods: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P <.001, non-SS > control P =.042, SS > non-SS P <.001; TNF-α: SS > control P =.006, non-SS > control P =.034, SS > non-SS P =.029; IL-6: SS > control P =.002, non-SS > control P =.032, SS > non-SS P =.002). IL-17 was significantly correlated with TBUT (R = -0.22, P =.012) and Schirmer I test (R = -0.36, P =.027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P =.02) in the non-SS group. Conclusions: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.

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