Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients

Sang Yeop Lee, Soo Jung Han, Sang Min Nam, Sang Chul Yoon, Ji Min Ahn, Tae Im Kim, Eung Kweon Kim, Kyoung Yul Seo

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Purpose: To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design: Prospective cross-sectional study. Methods: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P <.001, non-SS > control P =.042, SS > non-SS P <.001; TNF-α: SS > control P =.006, non-SS > control P =.034, SS > non-SS P =.029; IL-6: SS > control P =.002, non-SS > control P =.032, SS > non-SS P =.002). IL-17 was significantly correlated with TBUT (R = -0.22, P =.012) and Schirmer I test (R = -0.36, P =.027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P =.02) in the non-SS group. Conclusions: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.

Original languageEnglish
Pages (from-to)247-253.e1
JournalAmerican Journal of Ophthalmology
Volume156
Issue number2
DOIs
Publication statusPublished - 2013 Aug

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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