Analysis of the clinicopathological characteristics of gastric cancer in extremely old patients

Il Woong Sohn, Da Hyun Jung, Jie Hyun Kim, Hyun Soo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This study examined the clinicopathological characteristics of gastric cancer in extremely old (over 85 years) patients who received treatment or conservative observations and compared the treatment outcomes according to the treatment modality. Materials and Methods A total of 170 patients over 85 years of age were diagnosed with gastric cancer. Of these, 81 underwent treatment for gastric cancer and 89 received conservative observations. The clinicopathological characteristics of the treatment and conservative groups were compared. Results The mean age of the patients was 86.5 years. The conservative group included significantly more patients with older ages, macroscopically advanced cancer and upper-middle located cancer. The overall survival rate of the treatment group was significantly higher than that of the conservative group. The disease-specific mortality rate was significantly lower in the treatment group than in the conservative group. Multivariate analysis revealed the clinical course, alarm sign, and macroscopic classification to be independent prognosis factors. Conclusion By itself, the chronological age should not be used as a strategy to determine whether treatment will be administered for gastric cancer. Patients who have early gastric cancer or lowerrisk preexisting comorbidities should not be discouraged from treatment, even if they are older than 85 years.

Original languageEnglish
Pages (from-to)204-212
Number of pages9
JournalCancer Research and Treatment
Volume49
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Stomach Neoplasms
Clinical Alarms
Therapeutics
Neoplasms
Korea
Comorbidity
Multivariate Analysis
Survival Rate
Mortality
Population
Conservative Treatment

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Sohn, Il Woong ; Jung, Da Hyun ; Kim, Jie Hyun ; Chung, Hyun Soo ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, Sang Kil ; Lee, Yong Chan. / Analysis of the clinicopathological characteristics of gastric cancer in extremely old patients. In: Cancer Research and Treatment. 2017 ; Vol. 49, No. 1. pp. 204-212.
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abstract = "Purpose Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This study examined the clinicopathological characteristics of gastric cancer in extremely old (over 85 years) patients who received treatment or conservative observations and compared the treatment outcomes according to the treatment modality. Materials and Methods A total of 170 patients over 85 years of age were diagnosed with gastric cancer. Of these, 81 underwent treatment for gastric cancer and 89 received conservative observations. The clinicopathological characteristics of the treatment and conservative groups were compared. Results The mean age of the patients was 86.5 years. The conservative group included significantly more patients with older ages, macroscopically advanced cancer and upper-middle located cancer. The overall survival rate of the treatment group was significantly higher than that of the conservative group. The disease-specific mortality rate was significantly lower in the treatment group than in the conservative group. Multivariate analysis revealed the clinical course, alarm sign, and macroscopic classification to be independent prognosis factors. Conclusion By itself, the chronological age should not be used as a strategy to determine whether treatment will be administered for gastric cancer. Patients who have early gastric cancer or lowerrisk preexisting comorbidities should not be discouraged from treatment, even if they are older than 85 years.",
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Analysis of the clinicopathological characteristics of gastric cancer in extremely old patients. / Sohn, Il Woong; Jung, Da Hyun; Kim, Jie Hyun; Chung, Hyun Soo; Park, Jun Chul; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan.

In: Cancer Research and Treatment, Vol. 49, No. 1, 01.01.2017, p. 204-212.

Research output: Contribution to journalArticle

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AU - Shin, Sung Kwan

AU - Lee, Sang Kil

AU - Lee, Yong Chan

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N2 - Purpose Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This study examined the clinicopathological characteristics of gastric cancer in extremely old (over 85 years) patients who received treatment or conservative observations and compared the treatment outcomes according to the treatment modality. Materials and Methods A total of 170 patients over 85 years of age were diagnosed with gastric cancer. Of these, 81 underwent treatment for gastric cancer and 89 received conservative observations. The clinicopathological characteristics of the treatment and conservative groups were compared. Results The mean age of the patients was 86.5 years. The conservative group included significantly more patients with older ages, macroscopically advanced cancer and upper-middle located cancer. The overall survival rate of the treatment group was significantly higher than that of the conservative group. The disease-specific mortality rate was significantly lower in the treatment group than in the conservative group. Multivariate analysis revealed the clinical course, alarm sign, and macroscopic classification to be independent prognosis factors. Conclusion By itself, the chronological age should not be used as a strategy to determine whether treatment will be administered for gastric cancer. Patients who have early gastric cancer or lowerrisk preexisting comorbidities should not be discouraged from treatment, even if they are older than 85 years.

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