Analysis of the thermostability determinants of hyperthermophilic esterase EstE1 based on its predicted three-dimensional structure

Jin Kyu Rhee, Do Yun Kim, Dae Gyun Ahn, Jung Hyuk Yun, Seung Hwan Jang, Hang Cheol Shin, Hyun Soo Cho, Jae Gu Pan, Jong Won Oh

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Abstract

The three-dimensional (3D) structure of the hyperthermophilic esterase EstE1 was constructed by homology modeling using Archaeoglobus fulgidus esterase as a reference, and the thermostability-structure relationship was analyzed. Our results verified the predicted 3D structure of EstE1 and identified the ion pair networks and hydrophobic interactions that are critical determinants for the thermostability of EstE1.

Original languageEnglish
Pages (from-to)3021-3025
Number of pages5
JournalApplied and Environmental Microbiology
Volume72
Issue number4
DOIs
Publication statusPublished - 2006 Apr 1

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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