Abstract
Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.
| Original language | English |
|---|---|
| Pages (from-to) | 22183-22195 |
| Number of pages | 13 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 32 |
| DOIs | |
| Publication status | Published - 2014 Aug 8 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
}
Anamorsin, a novel caspase-3 substrate in neurodegeneration. / Yun, Nuri; Lee, Young Mook; Kim, Chiho; Shibayama, Hirohiko; Tanimura, Akira; Hamanaka, Yuri; Kanakura, Yuzuru; Park, Il Seon; Jo, Areum; Shin, Joo Ho; Ju, Chung; Kim, Won Ki; Oh, Young Jun.
In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22183-22195.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anamorsin, a novel caspase-3 substrate in neurodegeneration
AU - Yun, Nuri
AU - Lee, Young Mook
AU - Kim, Chiho
AU - Shibayama, Hirohiko
AU - Tanimura, Akira
AU - Hamanaka, Yuri
AU - Kanakura, Yuzuru
AU - Park, Il Seon
AU - Jo, Areum
AU - Shin, Joo Ho
AU - Ju, Chung
AU - Kim, Won Ki
AU - Oh, Young Jun
PY - 2014/8/8
Y1 - 2014/8/8
N2 - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.
AB - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.
UR - http://www.scopus.com/inward/record.url?scp=84905851425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905851425&partnerID=8YFLogxK
U2 - 10.1074/jbc.M114.552679
DO - 10.1074/jbc.M114.552679
M3 - Article
C2 - 24973211
AN - SCOPUS:84905851425
VL - 289
SP - 22183
EP - 22195
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 32
ER -