Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun; Young Mook Lee; Chiho Kim; Hirohiko Shibayama; Akira Tanimura; Yuri Hamanaka; Yuzuru Kanakura; Il Seon Park; Areum Jo; Joo Ho Shin; Chung Ju; Won Ki Kim; Young J. Oh

doi:10.1074/jbc.M114.552679

Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il Seon Park, Areum Jo, Joo Ho Shin, Chung Ju, Won Ki Kim, Young J. Oh

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original language	English
Pages (from-to)	22183-22195
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.552679
Publication status	Published - 2014 Aug 8

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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Yun, N., Lee, Y. M., Kim, C., Shibayama, H., Tanimura, A., Hamanaka, Y., Kanakura, Y., Park, I. S., Jo, A., Shin, J. H., Ju, C., Kim, W. K., & Oh, Y. J. (2014). Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry, 289(32), 22183-22195. https://doi.org/10.1074/jbc.M114.552679

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abstract = "Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.",

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Anamorsin, a novel caspase-3 substrate in neurodegeneration. / Yun, Nuri; Lee, Young Mook; Kim, Chiho; Shibayama, Hirohiko; Tanimura, Akira; Hamanaka, Yuri; Kanakura, Yuzuru; Park, Il Seon; Jo, Areum; Shin, Joo Ho; Ju, Chung; Kim, Won Ki; Oh, Young J.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22183-22195.

Research output: Contribution to journal › Article

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AU - Kim, Chiho

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AU - Tanimura, Akira

AU - Hamanaka, Yuri

AU - Kanakura, Yuzuru

AU - Park, Il Seon

AU - Jo, Areum

AU - Shin, Joo Ho

AU - Ju, Chung

AU - Kim, Won Ki

AU - Oh, Young J.

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AB - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

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