Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il Seon Park, Areum Jo, Joo Ho Shin, Chung Ju, Won Ki Kim, Young Jun Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original languageEnglish
Pages (from-to)22183-22195
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
Publication statusPublished - 2014 Aug 8

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Caspase 3
Substrates
Neurology
Cell death
Cell Death
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Yun, N., Lee, Y. M., Kim, C., Shibayama, H., Tanimura, A., Hamanaka, Y., ... Oh, Y. J. (2014). Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry, 289(32), 22183-22195. https://doi.org/10.1074/jbc.M114.552679
Yun, Nuri ; Lee, Young Mook ; Kim, Chiho ; Shibayama, Hirohiko ; Tanimura, Akira ; Hamanaka, Yuri ; Kanakura, Yuzuru ; Park, Il Seon ; Jo, Areum ; Shin, Joo Ho ; Ju, Chung ; Kim, Won Ki ; Oh, Young Jun. / Anamorsin, a novel caspase-3 substrate in neurodegeneration. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 32. pp. 22183-22195.
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Yun, N, Lee, YM, Kim, C, Shibayama, H, Tanimura, A, Hamanaka, Y, Kanakura, Y, Park, IS, Jo, A, Shin, JH, Ju, C, Kim, WK & Oh, YJ 2014, 'Anamorsin, a novel caspase-3 substrate in neurodegeneration', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22183-22195. https://doi.org/10.1074/jbc.M114.552679

Anamorsin, a novel caspase-3 substrate in neurodegeneration. / Yun, Nuri; Lee, Young Mook; Kim, Chiho; Shibayama, Hirohiko; Tanimura, Akira; Hamanaka, Yuri; Kanakura, Yuzuru; Park, Il Seon; Jo, Areum; Shin, Joo Ho; Ju, Chung; Kim, Won Ki; Oh, Young Jun.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22183-22195.

Research output: Contribution to journalArticle

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AU - Lee, Young Mook

AU - Kim, Chiho

AU - Shibayama, Hirohiko

AU - Tanimura, Akira

AU - Hamanaka, Yuri

AU - Kanakura, Yuzuru

AU - Park, Il Seon

AU - Jo, Areum

AU - Shin, Joo Ho

AU - Ju, Chung

AU - Kim, Won Ki

AU - Oh, Young Jun

PY - 2014/8/8

Y1 - 2014/8/8

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Yun N, Lee YM, Kim C, Shibayama H, Tanimura A, Hamanaka Y et al. Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry. 2014 Aug 8;289(32):22183-22195. https://doi.org/10.1074/jbc.M114.552679