Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer

Ik Yong Kim, Hye Yeon Kwon, Kwang Hwa Park, Dae Sung Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation of APC may be associated with tumorigenesis. This study examines the relationship between APC expression and clinicopathological factors and evaluates the possibility of an aberrant APC function in colorectal carcinomas (CRCs). Methods: To determine whether the loss of APC7 expression is related to tumorigenesis, we used tissue micro-arrays in 114 resected CRCs to scrutinize the expressions of APC7 and Ki-67 immunohistochemistry and to find relations with clinocopathologic parameters. The expression of APC7 was defined as positive for summed scores of staining intensities from 0 to 3+. Results: Forty-four cases (67.7%) of colon cancer and 38 cases (77.6%) of rectal cancer showed immunopositive reactions to APC. The grade of APC expression was not statistically correlated with tumor location, age, T or TNM stage, or differentiation. However, the expression of APC did correlate with the expression of Ki-67 and to the tumor recurrent. Higher APC expression showed the better 5-year overall survival rate in 74% of grades 2, 3 groups (high expression) than 57% of grades 0, 1 groups (lower expression) respectively (P = 0.042). Conclusion: Positive APC expression may be a good prognostic factor for patients with CRC, and the loss of APC expression in tumor tissue may be related with the risk for recurrence and a poor survival rate compared to high APC expression. Further study of APC in controlling the cell cycle as aberrant function in CRC is needed.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalAnnals of Coloproctology
Volume33
Issue number4
DOIs
Publication statusPublished - 2017 Aug

Fingerprint

Anaphase-Promoting Complex-Cyclosome
Colorectal Neoplasms
Carcinogenesis
Securin
Survival Rate
Cyclin B
Multiprotein Complexes
Neoplasms
Ubiquitin-Protein Ligases
Ubiquitination
Rectal Neoplasms
Oncogenes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Ik Yong ; Kwon, Hye Yeon ; Park, Kwang Hwa ; Kim, Dae Sung. / Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer. In: Annals of Coloproctology. 2017 ; Vol. 33, No. 4. pp. 139-145.
@article{8f738bbaea3e49f7bc7eedca3707b2d2,
title = "Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer",
abstract = "Purpose: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation of APC may be associated with tumorigenesis. This study examines the relationship between APC expression and clinicopathological factors and evaluates the possibility of an aberrant APC function in colorectal carcinomas (CRCs). Methods: To determine whether the loss of APC7 expression is related to tumorigenesis, we used tissue micro-arrays in 114 resected CRCs to scrutinize the expressions of APC7 and Ki-67 immunohistochemistry and to find relations with clinocopathologic parameters. The expression of APC7 was defined as positive for summed scores of staining intensities from 0 to 3+. Results: Forty-four cases (67.7{\%}) of colon cancer and 38 cases (77.6{\%}) of rectal cancer showed immunopositive reactions to APC. The grade of APC expression was not statistically correlated with tumor location, age, T or TNM stage, or differentiation. However, the expression of APC did correlate with the expression of Ki-67 and to the tumor recurrent. Higher APC expression showed the better 5-year overall survival rate in 74{\%} of grades 2, 3 groups (high expression) than 57{\%} of grades 0, 1 groups (lower expression) respectively (P = 0.042). Conclusion: Positive APC expression may be a good prognostic factor for patients with CRC, and the loss of APC expression in tumor tissue may be related with the risk for recurrence and a poor survival rate compared to high APC expression. Further study of APC in controlling the cell cycle as aberrant function in CRC is needed.",
author = "Kim, {Ik Yong} and Kwon, {Hye Yeon} and Park, {Kwang Hwa} and Kim, {Dae Sung}",
year = "2017",
month = "8",
doi = "10.3393/ac.2017.33.4.139",
language = "English",
volume = "33",
pages = "139--145",
journal = "Annals of Coloproctology",
issn = "2287-9714",
publisher = "Korean Society of Coloproctology",
number = "4",

}

Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer. / Kim, Ik Yong; Kwon, Hye Yeon; Park, Kwang Hwa; Kim, Dae Sung.

In: Annals of Coloproctology, Vol. 33, No. 4, 08.2017, p. 139-145.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anaphase-promoting complex 7 is a prognostic factor in human colorectal cancer

AU - Kim, Ik Yong

AU - Kwon, Hye Yeon

AU - Park, Kwang Hwa

AU - Kim, Dae Sung

PY - 2017/8

Y1 - 2017/8

N2 - Purpose: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation of APC may be associated with tumorigenesis. This study examines the relationship between APC expression and clinicopathological factors and evaluates the possibility of an aberrant APC function in colorectal carcinomas (CRCs). Methods: To determine whether the loss of APC7 expression is related to tumorigenesis, we used tissue micro-arrays in 114 resected CRCs to scrutinize the expressions of APC7 and Ki-67 immunohistochemistry and to find relations with clinocopathologic parameters. The expression of APC7 was defined as positive for summed scores of staining intensities from 0 to 3+. Results: Forty-four cases (67.7%) of colon cancer and 38 cases (77.6%) of rectal cancer showed immunopositive reactions to APC. The grade of APC expression was not statistically correlated with tumor location, age, T or TNM stage, or differentiation. However, the expression of APC did correlate with the expression of Ki-67 and to the tumor recurrent. Higher APC expression showed the better 5-year overall survival rate in 74% of grades 2, 3 groups (high expression) than 57% of grades 0, 1 groups (lower expression) respectively (P = 0.042). Conclusion: Positive APC expression may be a good prognostic factor for patients with CRC, and the loss of APC expression in tumor tissue may be related with the risk for recurrence and a poor survival rate compared to high APC expression. Further study of APC in controlling the cell cycle as aberrant function in CRC is needed.

AB - Purpose: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation of APC may be associated with tumorigenesis. This study examines the relationship between APC expression and clinicopathological factors and evaluates the possibility of an aberrant APC function in colorectal carcinomas (CRCs). Methods: To determine whether the loss of APC7 expression is related to tumorigenesis, we used tissue micro-arrays in 114 resected CRCs to scrutinize the expressions of APC7 and Ki-67 immunohistochemistry and to find relations with clinocopathologic parameters. The expression of APC7 was defined as positive for summed scores of staining intensities from 0 to 3+. Results: Forty-four cases (67.7%) of colon cancer and 38 cases (77.6%) of rectal cancer showed immunopositive reactions to APC. The grade of APC expression was not statistically correlated with tumor location, age, T or TNM stage, or differentiation. However, the expression of APC did correlate with the expression of Ki-67 and to the tumor recurrent. Higher APC expression showed the better 5-year overall survival rate in 74% of grades 2, 3 groups (high expression) than 57% of grades 0, 1 groups (lower expression) respectively (P = 0.042). Conclusion: Positive APC expression may be a good prognostic factor for patients with CRC, and the loss of APC expression in tumor tissue may be related with the risk for recurrence and a poor survival rate compared to high APC expression. Further study of APC in controlling the cell cycle as aberrant function in CRC is needed.

UR - http://www.scopus.com/inward/record.url?scp=85029487942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029487942&partnerID=8YFLogxK

U2 - 10.3393/ac.2017.33.4.139

DO - 10.3393/ac.2017.33.4.139

M3 - Article

AN - SCOPUS:85029487942

VL - 33

SP - 139

EP - 145

JO - Annals of Coloproctology

JF - Annals of Coloproctology

SN - 2287-9714

IS - 4

ER -