Anaphylactic transfusion reaction in a patient with anhaptoglobinemia: The first case in Korea

Hyunsoo Kim, Jonghyeon Choi, Kyoung Un Park, Hyonsuk Kim, Yoo Hong Min, Moon Jung Kim, Hyun Ok Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the frst case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.

Original languageEnglish
Pages (from-to)304-306
Number of pages3
JournalAnnals of laboratory medicine
Volume32
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Anaphylaxis
Korea
Platelets
Haptoglobins
Blood
Platelet Transfusion
Chemotherapy
Washing
Genes
Acute Promyelocytic Leukemia
Blood Component Removal
Antibodies
Multigene Family
Blood Transfusion
Thrombocytopenia
Transfusion Reaction
Hypersensitivity
Blood Platelets
Enzyme-Linked Immunosorbent Assay
Phenotype

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kim, Hyunsoo ; Choi, Jonghyeon ; Park, Kyoung Un ; Kim, Hyonsuk ; Min, Yoo Hong ; Kim, Moon Jung ; Kim, Hyun Ok. / Anaphylactic transfusion reaction in a patient with anhaptoglobinemia : The first case in Korea. In: Annals of laboratory medicine. 2012 ; Vol. 32, No. 4. pp. 304-306.
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Anaphylactic transfusion reaction in a patient with anhaptoglobinemia : The first case in Korea. / Kim, Hyunsoo; Choi, Jonghyeon; Park, Kyoung Un; Kim, Hyonsuk; Min, Yoo Hong; Kim, Moon Jung; Kim, Hyun Ok.

In: Annals of laboratory medicine, Vol. 32, No. 4, 01.07.2012, p. 304-306.

Research output: Contribution to journalArticle

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