Abstract
Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the frst case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
| Original language | English |
|---|---|
| Pages (from-to) | 304-306 |
| Number of pages | 3 |
| Journal | Annals of laboratory medicine |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Biochemistry, medical
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Anaphylactic transfusion reaction in a patient with anhaptoglobinemia : The first case in Korea. / Kim, Hyunsoo; Choi, Jonghyeon; Park, Kyoung Un; Kim, Hyon Suk; Min, Yoo Hong; Kim, Moon Jung; Kim, Hyun Ok.
In: Annals of laboratory medicine, Vol. 32, No. 4, 01.07.2012, p. 304-306.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anaphylactic transfusion reaction in a patient with anhaptoglobinemia
T2 - The first case in Korea
AU - Kim, Hyunsoo
AU - Choi, Jonghyeon
AU - Park, Kyoung Un
AU - Kim, Hyon Suk
AU - Min, Yoo Hong
AU - Kim, Moon Jung
AU - Kim, Hyun Ok
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the frst case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
AB - Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the frst case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
UR - http://www.scopus.com/inward/record.url?scp=84865963850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865963850&partnerID=8YFLogxK
U2 - 10.3343/alm.2012.32.4.304
DO - 10.3343/alm.2012.32.4.304
M3 - Article
C2 - 22779074
AN - SCOPUS:84865963850
VL - 32
SP - 304
EP - 306
JO - Annals of Laboratory Medicine
JF - Annals of Laboratory Medicine
SN - 2234-3806
IS - 4
ER -