Anaplastic transformation of papillary thyroid carcinoma in a young man: A case study with immunohistochemical and BRAF analysis

Ji Hye Park, Hyeong Ju Kwon, Cheong Soo Park, Soon Won Hong

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3 Citations (Scopus)


This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalKorean Journal of Pathology
Issue number3
Publication statusPublished - 2014


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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