Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention

Bon Kwon Koo, Katsuhisa Waseda, Hyun Jae Kang, Hyo Soo Kim, Chang Wook Nam, Seung Ho Hur, Jung Sun Kim, Donghoon Choi, Yangsoo Jang, Joo Yong Hahn, Hyeon Cheol Gwon, Myeong Ho Yoon, Seung Jea Tahk, Woo Young Chung, Young Seok Cho, Dong Ju Choi, Takao Hasegawa, Toru Kataoka, Sung Jin Oh, Yasuhiro HondaPeter J. Fitzgerald, William F. Fearon

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Background:We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant "jailed" side branch (SB) lesions. Methods and Results:Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before and after MB stent implantation, and fractional flow reserve was measured in the jailed SB. The vessel volume index of both the proximal and distal MB was increased after stent implantation. The plaque volume index decreased in the proximal MB (9.1±3.0 to 8.4±2.4 mm3/mm, P=0.001), implicating plaque shift, but not in the distal MB (5.4± 1.8 to 5.3 ± 1.7 mm3/mm, P=0.227), implicating carina shifting to account for the change in vessel size (N=56). The mean SB fractional flow reserve was 0.71 ±0.20 (N=68) and 43% of the lesions were functionally significant. Binary logistic-regression analysis revealed that preintervention % diameter stenosis of the SB (odds ratio=1.05; 95% CI, 1.01 to 1.09) and the MB minimum lumen diameter located distal to the SB ostium (odds ratio=3.86; 95% CI, 1.03 to 14.43) were independent predictors of functionally significant SB jailing. In patients with ≥75% stenosis and Thrombolysis In Myocardial Infarction grade 3 flow in the SB, no difference in poststent angiographic and intravascular ultrasound parameters was found between SB lesions with and without functional significance. Conclusions:Both plaque shift from the MB and carina shift contribute to the creation/aggravation of an SB ostial lesion after MB stent implantation. Anatomic evaluation does not reliably predict the functional significance of a jailed SB stenosis.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalCirculation: Cardiovascular Interventions
Volume3
Issue number2
DOIs
Publication statusPublished - 2010 Apr 1

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Percutaneous Coronary Intervention
Stents
Pathologic Constriction
Odds Ratio
Logistic Models
Myocardial Infarction
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Koo, Bon Kwon ; Waseda, Katsuhisa ; Kang, Hyun Jae ; Kim, Hyo Soo ; Nam, Chang Wook ; Hur, Seung Ho ; Kim, Jung Sun ; Choi, Donghoon ; Jang, Yangsoo ; Hahn, Joo Yong ; Gwon, Hyeon Cheol ; Yoon, Myeong Ho ; Tahk, Seung Jea ; Chung, Woo Young ; Cho, Young Seok ; Choi, Dong Ju ; Hasegawa, Takao ; Kataoka, Toru ; Oh, Sung Jin ; Honda, Yasuhiro ; Fitzgerald, Peter J. ; Fearon, William F. / Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention. In: Circulation: Cardiovascular Interventions. 2010 ; Vol. 3, No. 2. pp. 113-119.
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title = "Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention",
abstract = "Background:We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant {"}jailed{"} side branch (SB) lesions. Methods and Results:Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before and after MB stent implantation, and fractional flow reserve was measured in the jailed SB. The vessel volume index of both the proximal and distal MB was increased after stent implantation. The plaque volume index decreased in the proximal MB (9.1±3.0 to 8.4±2.4 mm3/mm, P=0.001), implicating plaque shift, but not in the distal MB (5.4± 1.8 to 5.3 ± 1.7 mm3/mm, P=0.227), implicating carina shifting to account for the change in vessel size (N=56). The mean SB fractional flow reserve was 0.71 ±0.20 (N=68) and 43{\%} of the lesions were functionally significant. Binary logistic-regression analysis revealed that preintervention {\%} diameter stenosis of the SB (odds ratio=1.05; 95{\%} CI, 1.01 to 1.09) and the MB minimum lumen diameter located distal to the SB ostium (odds ratio=3.86; 95{\%} CI, 1.03 to 14.43) were independent predictors of functionally significant SB jailing. In patients with ≥75{\%} stenosis and Thrombolysis In Myocardial Infarction grade 3 flow in the SB, no difference in poststent angiographic and intravascular ultrasound parameters was found between SB lesions with and without functional significance. Conclusions:Both plaque shift from the MB and carina shift contribute to the creation/aggravation of an SB ostial lesion after MB stent implantation. Anatomic evaluation does not reliably predict the functional significance of a jailed SB stenosis.",
author = "Koo, {Bon Kwon} and Katsuhisa Waseda and Kang, {Hyun Jae} and Kim, {Hyo Soo} and Nam, {Chang Wook} and Hur, {Seung Ho} and Kim, {Jung Sun} and Donghoon Choi and Yangsoo Jang and Hahn, {Joo Yong} and Gwon, {Hyeon Cheol} and Yoon, {Myeong Ho} and Tahk, {Seung Jea} and Chung, {Woo Young} and Cho, {Young Seok} and Choi, {Dong Ju} and Takao Hasegawa and Toru Kataoka and Oh, {Sung Jin} and Yasuhiro Honda and Fitzgerald, {Peter J.} and Fearon, {William F.}",
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language = "English",
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journal = "Circulation: Cardiovascular Interventions",
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Koo, BK, Waseda, K, Kang, HJ, Kim, HS, Nam, CW, Hur, SH, Kim, JS, Choi, D, Jang, Y, Hahn, JY, Gwon, HC, Yoon, MH, Tahk, SJ, Chung, WY, Cho, YS, Choi, DJ, Hasegawa, T, Kataoka, T, Oh, SJ, Honda, Y, Fitzgerald, PJ & Fearon, WF 2010, 'Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention', Circulation: Cardiovascular Interventions, vol. 3, no. 2, pp. 113-119. https://doi.org/10.1161/CIRCINTERVENTIONS.109.887406

Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention. / Koo, Bon Kwon; Waseda, Katsuhisa; Kang, Hyun Jae; Kim, Hyo Soo; Nam, Chang Wook; Hur, Seung Ho; Kim, Jung Sun; Choi, Donghoon; Jang, Yangsoo; Hahn, Joo Yong; Gwon, Hyeon Cheol; Yoon, Myeong Ho; Tahk, Seung Jea; Chung, Woo Young; Cho, Young Seok; Choi, Dong Ju; Hasegawa, Takao; Kataoka, Toru; Oh, Sung Jin; Honda, Yasuhiro; Fitzgerald, Peter J.; Fearon, William F.

In: Circulation: Cardiovascular Interventions, Vol. 3, No. 2, 01.04.2010, p. 113-119.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention

AU - Koo, Bon Kwon

AU - Waseda, Katsuhisa

AU - Kang, Hyun Jae

AU - Kim, Hyo Soo

AU - Nam, Chang Wook

AU - Hur, Seung Ho

AU - Kim, Jung Sun

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Hahn, Joo Yong

AU - Gwon, Hyeon Cheol

AU - Yoon, Myeong Ho

AU - Tahk, Seung Jea

AU - Chung, Woo Young

AU - Cho, Young Seok

AU - Choi, Dong Ju

AU - Hasegawa, Takao

AU - Kataoka, Toru

AU - Oh, Sung Jin

AU - Honda, Yasuhiro

AU - Fitzgerald, Peter J.

AU - Fearon, William F.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Background:We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant "jailed" side branch (SB) lesions. Methods and Results:Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before and after MB stent implantation, and fractional flow reserve was measured in the jailed SB. The vessel volume index of both the proximal and distal MB was increased after stent implantation. The plaque volume index decreased in the proximal MB (9.1±3.0 to 8.4±2.4 mm3/mm, P=0.001), implicating plaque shift, but not in the distal MB (5.4± 1.8 to 5.3 ± 1.7 mm3/mm, P=0.227), implicating carina shifting to account for the change in vessel size (N=56). The mean SB fractional flow reserve was 0.71 ±0.20 (N=68) and 43% of the lesions were functionally significant. Binary logistic-regression analysis revealed that preintervention % diameter stenosis of the SB (odds ratio=1.05; 95% CI, 1.01 to 1.09) and the MB minimum lumen diameter located distal to the SB ostium (odds ratio=3.86; 95% CI, 1.03 to 14.43) were independent predictors of functionally significant SB jailing. In patients with ≥75% stenosis and Thrombolysis In Myocardial Infarction grade 3 flow in the SB, no difference in poststent angiographic and intravascular ultrasound parameters was found between SB lesions with and without functional significance. Conclusions:Both plaque shift from the MB and carina shift contribute to the creation/aggravation of an SB ostial lesion after MB stent implantation. Anatomic evaluation does not reliably predict the functional significance of a jailed SB stenosis.

AB - Background:We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant "jailed" side branch (SB) lesions. Methods and Results:Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before and after MB stent implantation, and fractional flow reserve was measured in the jailed SB. The vessel volume index of both the proximal and distal MB was increased after stent implantation. The plaque volume index decreased in the proximal MB (9.1±3.0 to 8.4±2.4 mm3/mm, P=0.001), implicating plaque shift, but not in the distal MB (5.4± 1.8 to 5.3 ± 1.7 mm3/mm, P=0.227), implicating carina shifting to account for the change in vessel size (N=56). The mean SB fractional flow reserve was 0.71 ±0.20 (N=68) and 43% of the lesions were functionally significant. Binary logistic-regression analysis revealed that preintervention % diameter stenosis of the SB (odds ratio=1.05; 95% CI, 1.01 to 1.09) and the MB minimum lumen diameter located distal to the SB ostium (odds ratio=3.86; 95% CI, 1.03 to 14.43) were independent predictors of functionally significant SB jailing. In patients with ≥75% stenosis and Thrombolysis In Myocardial Infarction grade 3 flow in the SB, no difference in poststent angiographic and intravascular ultrasound parameters was found between SB lesions with and without functional significance. Conclusions:Both plaque shift from the MB and carina shift contribute to the creation/aggravation of an SB ostial lesion after MB stent implantation. Anatomic evaluation does not reliably predict the functional significance of a jailed SB stenosis.

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U2 - 10.1161/CIRCINTERVENTIONS.109.887406

DO - 10.1161/CIRCINTERVENTIONS.109.887406

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