Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines

Kyu Ho Yi, Ji Hyun Lee, Hye Won Hu, Hee Jin Kim

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Botulinum neurotoxin injection for treating glabellar frown lines is a commonly used method; however, side effects, such as ptosis and samurai eyebrow, have been reported due to a lack of comprehensive anatomical knowledge. The anatomical factors important for the injection of the botulinum neurotoxin into the corrugator supercilii muscle has been reviewed in this study. Current understanding on the localization of the botulinum neurotoxin injection point from newer anatomy examination was evaluated. We observed that for the glabellar-frown-line-related mus-cles, the injection point could be more accurately demarcated. We propose the injection method and the best possible injection sites for the corrugator supercilii muscle. We propose the optimal injection sites using external anatomical landmarks for the frequently injected muscles of the face to accelerate effective glabellar frown line removal. Moreover, these instructions would support a more accurate procedure without adverse events.

Original languageEnglish
Article number268
Issue number4
Publication statusPublished - 2022 Apr

Bibliographical note

Funding Information:
Funding: This work was supported by the Korea Medical Device Development Fund grant, funded by the Korean government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: 1711138194, KMDF_PR_20200901_0109-01).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines'. Together they form a unique fingerprint.

Cite this