Anatomy and physiology of the basal ganglia: Implications for deep brain stimulation for Parkinson's disease

Brian H. Kopell, Ali R. Rezai, Jin Woo Chang, Jerrold L. Vitek

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Central to surgical management of movement disorders is an understanding of the anatomy and physiology of the basal ganglia. The basal ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in the late 1930s. With the development of deep brain stimulation as the gold standard of surgical intervention for movement disorders, there has been a concomitant evolution in the understanding of the role the basal ganglia plays in the genesis of normal and abnormal motor behaviors. The fundamental concept of the cortico-striato-pallido-thalamocortical loop will be explored in the context of deep brain stimulation. The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current physiological and anatomical models of Parkinson's disease (PD). Finally, the current understandings of the mechanisms underpinning the beneficial effects of deep brain stimulation for PD will be discussed.

Original languageEnglish
Pages (from-to)S238-S246
JournalMovement Disorders
Volume21
Issue numberSUPPL. 14
DOIs
Publication statusPublished - 2006 Jul 17

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Deep Brain Stimulation
Basal Ganglia
Parkinson Disease
Anatomy
Movement Disorders
Anatomic Models
Subthalamic Nucleus
Globus Pallidus

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kopell, Brian H. ; Rezai, Ali R. ; Chang, Jin Woo ; Vitek, Jerrold L. / Anatomy and physiology of the basal ganglia : Implications for deep brain stimulation for Parkinson's disease. In: Movement Disorders. 2006 ; Vol. 21, No. SUPPL. 14. pp. S238-S246.
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Anatomy and physiology of the basal ganglia : Implications for deep brain stimulation for Parkinson's disease. / Kopell, Brian H.; Rezai, Ali R.; Chang, Jin Woo; Vitek, Jerrold L.

In: Movement Disorders, Vol. 21, No. SUPPL. 14, 17.07.2006, p. S238-S246.

Research output: Contribution to journalArticle

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