ANCA-associated vasculitis after scrub typhus

Yoon Kang, Hui Won Jang, Sang Hoon Han, Su Jin Jeong, Nam Su Ku, Ji Hyeon Baek, Chang Oh Kim, Jun Yong Choi, Young Goo Song, Sarah Lee, Yong Beom Park, Soo Kon Lee, Seung Min Kim, June Myung Kim

Research output: Contribution to journalArticle

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Abstract

Anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitis is a primary systemic vasculitis that affects the small vessels, and ANCA is involved as the common pathogenesis. Environmental factors such as infectious agents have been considered to play a role in triggering the autoimmunity. We report here on a case of ANCA-associated vasculitis that developed after scrub typhus. A 64-year-old male was admitted because of fever, chills, pain, weakness and hypoesthesia of his calves. He was diagnosed as having scrub typhus based on the findings of an eschar and the positive serum anti-orientia antibody. The fever continued despite the antibiotic treatment. Neurologic symptoms such as numbness, hypoesthesia and weakness began to develop in the hands, feet and calves with a persisting fever. The nerve conduction velocity study revealed mononeuritis multiplex of the superficial peroneal nerve and the median nerve. Microscopic hematuria then additionally developed, and the serology showed a positive myeloperoxidase (MPO) test. A nerve biopsy was conducted on the left superficial peroneal nerve and the result showed non-infectious systemic vasculitis of the mediumsmall arteries. He was diagnosed as having microscopic polyangiitis along with ANCA associated vasculitis. The fever resolved and the neurologic symptoms began to improve after steroid pulse treatment (methylprednisolone 1 g/day). The neuropathy gradually improved after discharge. We presume that the ANCAassociated vasculitis was triggered by scrub typhus.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalInfection and Chemotherapy
Volume43
Issue number1
DOIs
Publication statusPublished - 2011 Feb 1

Fingerprint

Scrub Typhus
Vasculitis
Hypesthesia
Fever
Systemic Vasculitis
Peroneal Nerve
Antibodies
Neurologic Manifestations
Microscopic Polyangiitis
Mononeuropathies
Chills
Median Nerve
Neural Conduction
Methylprednisolone
Hematuria
Serology
Autoimmunity
Peroxidase
Foot
Anti-Idiotypic Antibodies

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Kang, Y., Jang, H. W., Han, S. H., Jeong, S. J., Ku, N. S., Baek, J. H., ... Kim, J. M. (2011). ANCA-associated vasculitis after scrub typhus. Infection and Chemotherapy, 43(1), 82-85. https://doi.org/10.3947/ic.2011.43.1.82
Kang, Yoon ; Jang, Hui Won ; Han, Sang Hoon ; Jeong, Su Jin ; Ku, Nam Su ; Baek, Ji Hyeon ; Kim, Chang Oh ; Choi, Jun Yong ; Song, Young Goo ; Lee, Sarah ; Park, Yong Beom ; Lee, Soo Kon ; Kim, Seung Min ; Kim, June Myung. / ANCA-associated vasculitis after scrub typhus. In: Infection and Chemotherapy. 2011 ; Vol. 43, No. 1. pp. 82-85.
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Kang, Y, Jang, HW, Han, SH, Jeong, SJ, Ku, NS, Baek, JH, Kim, CO, Choi, JY, Song, YG, Lee, S, Park, YB, Lee, SK, Kim, SM & Kim, JM 2011, 'ANCA-associated vasculitis after scrub typhus', Infection and Chemotherapy, vol. 43, no. 1, pp. 82-85. https://doi.org/10.3947/ic.2011.43.1.82

ANCA-associated vasculitis after scrub typhus. / Kang, Yoon; Jang, Hui Won; Han, Sang Hoon; Jeong, Su Jin; Ku, Nam Su; Baek, Ji Hyeon; Kim, Chang Oh; Choi, Jun Yong; Song, Young Goo; Lee, Sarah; Park, Yong Beom; Lee, Soo Kon; Kim, Seung Min; Kim, June Myung.

In: Infection and Chemotherapy, Vol. 43, No. 1, 01.02.2011, p. 82-85.

Research output: Contribution to journalArticle

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AU - Kim, Chang Oh

AU - Choi, Jun Yong

AU - Song, Young Goo

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Kang Y, Jang HW, Han SH, Jeong SJ, Ku NS, Baek JH et al. ANCA-associated vasculitis after scrub typhus. Infection and Chemotherapy. 2011 Feb 1;43(1):82-85. https://doi.org/10.3947/ic.2011.43.1.82