ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis

Jung Yoon Pyo, Seung Min Jung, Jason Jungsik Song, YongBeom Park, Sang Won Lee

Research output: Contribution to journalReview article

Abstract

We investigated the association of antineutrophil cytoplasmic antibody (ANCA) positivity with lupus nephritis (LN) activity, histological features and prognosis in Korean patients with biopsy-proven LN having the results of both myeloperoxidase (MPO–ANCA) and proteinase 3 (PR3)–ANCA. We retrospectively reviewed the medical records of 91 LN patients having the results of ANCA. We divided patients with LN into the two groups according to the ANCA positivity. We collected clinical and laboratory data at kidney biopsy and histological features such as LN class including class I, II, III, IV-S, IV-G and V, and activity and chronicity index. We evaluated prognosis of LN during the follow-up by death and kidney failure. Twelve of 91 patients (13.2%) had ANCA at kidney biopsy. There were no differences in demographic data, comorbidities, reasons for kidney biopsy and laboratory data at kidney biopsy between patients with and without ANCA. In 12 LN patients with ANCA, Class III was the most frequently observed LN class (41.7%), while in 79 LN patients without ANCA, class IV-G was the most often detected LN class (35.4%). There were no meaningful differences in classes of LN between the two groups. On the other hand, patients with ANCA exhibited the higher median chronicity index than those without (2.5 vs. 1.0, P = 0.028), unlike activity index. ANCA positivity exhibited no association with death or kidney failure during the follow-up. ANCA positivity at kidney biopsy is associated with chronicity index of LN.

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalRheumatology International
Volume39
Issue number5
DOIs
Publication statusPublished - 2019 May 1

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Antineutrophil Cytoplasmic Antibodies
Lupus Nephritis
Kidney
Biopsy
Immunoglobulin Isotypes
Renal Insufficiency
Myeloblastin
Peroxidase
Medical Records
Comorbidity

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Pyo, Jung Yoon ; Jung, Seung Min ; Song, Jason Jungsik ; Park, YongBeom ; Lee, Sang Won. / ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis. In: Rheumatology International. 2019 ; Vol. 39, No. 5. pp. 879-884.
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abstract = "We investigated the association of antineutrophil cytoplasmic antibody (ANCA) positivity with lupus nephritis (LN) activity, histological features and prognosis in Korean patients with biopsy-proven LN having the results of both myeloperoxidase (MPO–ANCA) and proteinase 3 (PR3)–ANCA. We retrospectively reviewed the medical records of 91 LN patients having the results of ANCA. We divided patients with LN into the two groups according to the ANCA positivity. We collected clinical and laboratory data at kidney biopsy and histological features such as LN class including class I, II, III, IV-S, IV-G and V, and activity and chronicity index. We evaluated prognosis of LN during the follow-up by death and kidney failure. Twelve of 91 patients (13.2{\%}) had ANCA at kidney biopsy. There were no differences in demographic data, comorbidities, reasons for kidney biopsy and laboratory data at kidney biopsy between patients with and without ANCA. In 12 LN patients with ANCA, Class III was the most frequently observed LN class (41.7{\%}), while in 79 LN patients without ANCA, class IV-G was the most often detected LN class (35.4{\%}). There were no meaningful differences in classes of LN between the two groups. On the other hand, patients with ANCA exhibited the higher median chronicity index than those without (2.5 vs. 1.0, P = 0.028), unlike activity index. ANCA positivity exhibited no association with death or kidney failure during the follow-up. ANCA positivity at kidney biopsy is associated with chronicity index of LN.",
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ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis. / Pyo, Jung Yoon; Jung, Seung Min; Song, Jason Jungsik; Park, YongBeom; Lee, Sang Won.

In: Rheumatology International, Vol. 39, No. 5, 01.05.2019, p. 879-884.

Research output: Contribution to journalReview article

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T1 - ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis

AU - Pyo, Jung Yoon

AU - Jung, Seung Min

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