Anemia and incidence of dementia in patients with new-onset type 2 diabetes: A nationwide population-based cohort study

Jae Woo Choi, Tae Hyun Kim, Euna Han

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction This study aimed to examine the association between anemia and the incidence of dementia in patients with new-onset type 2 diabetes. Research design and methods This study used the Korean National Health Insurance Service-Health Screening Cohort and included 32 590 participants aged ≥40 years who were diagnosed with new-onset type 2 diabetes between 2004 and 2007 and followed up until 2013. Anemia was defined according to the criteria provided by the WHO, hemoglobin <120 g/L for women and <130 g/L for men, and was measured from after diagnosis date of type 2 diabetes to 2007. Dementia was defined by the Classification of Diseases 10th revision code as primary diagnosis and was measured from after hemoglobin measurement to 2013. We calculated the adjusted HR (AHR) and 95% CI to assess the risk of dementia using multivariable Cox proportional hazards regression models. Results We identified 1682 patients who developed dementia within a 7.5-year follow-up. Among patients with type 2 diabetes, patients with anemia were associated with an increased risk of dementia than those without anemia (AHR, 1.21; 95% CI 1.06 to 1.39). Patients with mild (AHR, 1.18; 95% CI 1.03 to 1.38) and moderate (AHR, 1.39; 95% CI 1.06 to 1.83) anemia were associated with an increased risk of dementia than those without anemia among patients with type 2 diabetes. Men (AHR, 1.47; 95% CI 1.16 to 1.83) and middle-aged adults (AHR, 1.31; 95% CI 1.03 to 1.75) with anemia were associated with an increased risk of dementia than their counterparts without anemia among patients with type 2 diabetes. Conclusions Our findings suggest that anemia is significantly associated with an increased risk of dementia among patients with newly diagnosed type 2 diabetes.

Original languageEnglish
Article numbere001289
JournalBMJ Open Diabetes Research and Care
Volume8
Issue number1
DOIs
Publication statusPublished - 2020 Aug 2

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (grant number: 2019R1A2C1003259, 2019K2A9A2A08000108, and 2020R1I1A1A01053104).

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Anemia and incidence of dementia in patients with new-onset type 2 diabetes: A nationwide population-based cohort study'. Together they form a unique fingerprint.

Cite this