Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon, Nuriye Korkmaz Zirpel, Hyun Ji Park, Sewoon Han, Kyung Hoon Hwang, Jisoo Shin, Seung-Woo Cho, Chang Hoon Nam, Seok Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalAdvanced healthcare materials
Volume5
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

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Vascular Endothelial Growth Factors
Bacteriophages
Collagen Type I
Collagen
Vascular Endothelial Growth Factor A
Extracellular Matrix
Nanofibers
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Endothelial cells
Gelation

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Yoon, Junghyo ; Korkmaz Zirpel, Nuriye ; Park, Hyun Ji ; Han, Sewoon ; Hwang, Kyung Hoon ; Shin, Jisoo ; Cho, Seung-Woo ; Nam, Chang Hoon ; Chung, Seok. / Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors. In: Advanced healthcare materials. 2016 ; Vol. 5, No. 2. pp. 205-212.
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Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors. / Yoon, Junghyo; Korkmaz Zirpel, Nuriye; Park, Hyun Ji; Han, Sewoon; Hwang, Kyung Hoon; Shin, Jisoo; Cho, Seung-Woo; Nam, Chang Hoon; Chung, Seok.

In: Advanced healthcare materials, Vol. 5, No. 2, 01.01.2016, p. 205-212.

Research output: Contribution to journalArticle

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AU - Yoon, Junghyo

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AU - Hwang, Kyung Hoon

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