Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon, Nuriye Korkmaz Zirpel, Hyun Ji Park, Sewoon Han, Kyung Hoon Hwang, Jisoo Shin, Seung-Woo Cho, Chang Hoon Nam, Seok Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalAdvanced healthcare materials
Volume5
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

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All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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