Angiographic and intravascular ultrasound follow up of paclitaxel- and sirolimus-eluting stent after poststent high-pressure balloon dilation: From the poststent optimal stent expansion trial

Sang Min Park, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Myeongki Hong, Yangsoo Jang, Woong Chol Kang, Taehoon Ahn, Byoung Keuk Kim, Seong Jin Oh, Dong Woon Jeon, Joo Young Yang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug-eluting stent (DES) and compare paclitaxel-eluting stent (PES) to sirolimus-eluting stent (SES). Background: Although poststent high-pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods: Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9-month follow-up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in-stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results: At 9-month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm 2 ) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7%) and 4 (3.4%), P = 0.004; NV index: 1.02 ± 0.99 mm 2 and 0.21 ± 0.37, P < 0.001 in PES and SES]. Conclusions: OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high-pressure balloon dilatation.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Volume77
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Sirolimus
Paclitaxel
Stents
Dilatation
Pressure
Neointima
Drug-Eluting Stents

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Park, Sang Min ; Kim, Jung Sun ; Ko, Young Guk ; Choi, Donghoon ; Hong, Myeongki ; Jang, Yangsoo ; Kang, Woong Chol ; Ahn, Taehoon ; Kim, Byoung Keuk ; Oh, Seong Jin ; Jeon, Dong Woon ; Yang, Joo Young. / Angiographic and intravascular ultrasound follow up of paclitaxel- and sirolimus-eluting stent after poststent high-pressure balloon dilation : From the poststent optimal stent expansion trial. In: Catheterization and Cardiovascular Interventions. 2011 ; Vol. 77, No. 1. pp. 15-21.
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title = "Angiographic and intravascular ultrasound follow up of paclitaxel- and sirolimus-eluting stent after poststent high-pressure balloon dilation: From the poststent optimal stent expansion trial",
abstract = "Objectives: The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug-eluting stent (DES) and compare paclitaxel-eluting stent (PES) to sirolimus-eluting stent (SES). Background: Although poststent high-pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods: Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9-month follow-up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in-stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results: At 9-month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm 2 ) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7{\%}) and 4 (3.4{\%}), P = 0.004; NV index: 1.02 ± 0.99 mm 2 and 0.21 ± 0.37, P < 0.001 in PES and SES]. Conclusions: OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high-pressure balloon dilatation.",
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Angiographic and intravascular ultrasound follow up of paclitaxel- and sirolimus-eluting stent after poststent high-pressure balloon dilation : From the poststent optimal stent expansion trial. / Park, Sang Min; Kim, Jung Sun; Ko, Young Guk; Choi, Donghoon; Hong, Myeongki; Jang, Yangsoo; Kang, Woong Chol; Ahn, Taehoon; Kim, Byoung Keuk; Oh, Seong Jin; Jeon, Dong Woon; Yang, Joo Young.

In: Catheterization and Cardiovascular Interventions, Vol. 77, No. 1, 01.01.2011, p. 15-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Angiographic and intravascular ultrasound follow up of paclitaxel- and sirolimus-eluting stent after poststent high-pressure balloon dilation

T2 - From the poststent optimal stent expansion trial

AU - Park, Sang Min

AU - Kim, Jung Sun

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Hong, Myeongki

AU - Jang, Yangsoo

AU - Kang, Woong Chol

AU - Ahn, Taehoon

AU - Kim, Byoung Keuk

AU - Oh, Seong Jin

AU - Jeon, Dong Woon

AU - Yang, Joo Young

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objectives: The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug-eluting stent (DES) and compare paclitaxel-eluting stent (PES) to sirolimus-eluting stent (SES). Background: Although poststent high-pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods: Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9-month follow-up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in-stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results: At 9-month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm 2 ) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7%) and 4 (3.4%), P = 0.004; NV index: 1.02 ± 0.99 mm 2 and 0.21 ± 0.37, P < 0.001 in PES and SES]. Conclusions: OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high-pressure balloon dilatation.

AB - Objectives: The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug-eluting stent (DES) and compare paclitaxel-eluting stent (PES) to sirolimus-eluting stent (SES). Background: Although poststent high-pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods: Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9-month follow-up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in-stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results: At 9-month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm 2 ) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7%) and 4 (3.4%), P = 0.004; NV index: 1.02 ± 0.99 mm 2 and 0.21 ± 0.37, P < 0.001 in PES and SES]. Conclusions: OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high-pressure balloon dilatation.

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