Abstract
Objective: This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months. Method: Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation. Results: The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy. Conclusion: Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.
| Original language | English |
|---|---|
| Pages (from-to) | 283-290 |
| Number of pages | 8 |
| Journal | Acta Psychiatrica Scandinavica |
| Volume | 107 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2003 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
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Anterior cingulotomy for refractory obsessive-compulsive disorder. / Kim, C. H.; Chang, J. W.; Koo, Min Seong; Kim, J. W.; Suh, H. S.; Park, I. H.; Lee, H. S.
In: Acta Psychiatrica Scandinavica, Vol. 107, No. 4, 01.04.2003, p. 283-290.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anterior cingulotomy for refractory obsessive-compulsive disorder
AU - Kim, C. H.
AU - Chang, J. W.
AU - Koo, Min Seong
AU - Kim, J. W.
AU - Suh, H. S.
AU - Park, I. H.
AU - Lee, H. S.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Objective: This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months. Method: Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation. Results: The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy. Conclusion: Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.
AB - Objective: This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months. Method: Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation. Results: The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy. Conclusion: Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.
UR - http://www.scopus.com/inward/record.url?scp=0345503058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345503058&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0447.2003.00087.x
DO - 10.1034/j.1600-0447.2003.00087.x
M3 - Article
C2 - 12662251
AN - SCOPUS:0345503058
VL - 107
SP - 283
EP - 290
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 4
ER -