Anterior lamina cribrosa surface depth in open-angle glaucoma: Relationship with the position of the central retinal vessel trunk

Baek Lok Oh, Eun Ji Lee, Hyunjoong Kim, Michaël J.A. Girard, Jean Martial Mari, Tae Woo Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To determine the factors influencing the anterior lamina cribrosa (LC) surface depth (LCD) in patients with open-angle glaucoma (OAG), focusing on the association between LCD and the position of the central retinal vessel trunk (CRVT) at the anterior LC surface. Methods: Optic nerve heads of 205 OAG eyes were scanned using swept-source optical coherence tomography (SS-OCT). After processing the images using adaptive compensation, the LCD was determined from 11 horizontal B-scan images that divided the optic disc vertically into 12 equal parts. Eyes were divided into two groups (central or peripheral) according to where the CRVT exits from the anterior LC surface. The influence of CRVT position on LCD was evaluated, taking into account age, gender, untreated intraocular pressure (IOP), IOP at optic-disc scanning, retinal nerve fiber layer (RNFL) thickness, visual-field mean deviation, central corneal thickness, and axial length. Results: Patients in the peripheral CRVT group were younger and more myopic, and had a larger mean LCD and thinner global RNFL than those in the central CRVT group (all P≤0.023). On multivariate analysis, the peripheral CRVT location was significantly associated with a larger LCD (P = 0.002), together with the significant association of younger age (P<0.001), higher untreated IOP (P = 0.010), and thinner RNFL (P = 0.003) on the larger LCD. Conclusion: In OAG, CRVT location was an independent factor influencing the LCD, together with age, untreated IOP, and global RNFL thickness. The data indicate that the CRVT may contribute to the resistance of the LC against deformation. A longitudinal prospective observation is required to clarify this relationship.

Original languageEnglish
Article numbere0158443
JournalPloS one
Volume11
Issue number6
DOIs
Publication statusPublished - 2016 Jun

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Retinal Vessels
glaucoma
Open Angle Glaucoma
laminae (animals)
Intraocular Pressure
Nerve Fibers
nerve fibers
Optic Disk
optics
Optics
Fibers
eyes
Optical Coherence Tomography
Visual Fields
Optical tomography
tomography
Multivariate Analysis
multivariate analysis
Observation
nerve tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Oh, Baek Lok ; Lee, Eun Ji ; Kim, Hyunjoong ; Girard, Michaël J.A. ; Mari, Jean Martial ; Kim, Tae Woo. / Anterior lamina cribrosa surface depth in open-angle glaucoma : Relationship with the position of the central retinal vessel trunk. In: PloS one. 2016 ; Vol. 11, No. 6.
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Anterior lamina cribrosa surface depth in open-angle glaucoma : Relationship with the position of the central retinal vessel trunk. / Oh, Baek Lok; Lee, Eun Ji; Kim, Hyunjoong; Girard, Michaël J.A.; Mari, Jean Martial; Kim, Tae Woo.

In: PloS one, Vol. 11, No. 6, e0158443, 06.2016.

Research output: Contribution to journalArticle

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AU - Mari, Jean Martial

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