Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences

Terence A. Ketter, Paul J. Andreason, Mark S. George, Chul Hee Lee, Debra S. Gill, Priti Z. Parekh, Mark W. Willis, Peter Herscovitch, Robert M. Post

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Background: Procaine activates limbic structures in animals. In humans, acute intravenous administration of procaine yields emotional and psychosensory experiences and temporal lobe fast activity. We studied procaine's acute effects on cerebral blood flow (CBF) in relationship to clinical responses. Methods: Cerebral blood flow was assessed by positron emission tomography with oxygen-15-labeled water in 32 healthy volunteers. Data were analyzed with statistical parametric mapping and magnetic resonance imaging-directed regions of interest. Results: Procaine increased global CBF and, to a greater extent, anterior paralimbic CBF. Subjects with intense procaine-induced fear compared with those with euphoria had greater increases in left amygdalar CBF. Absolute and normalized left amygdalar CBF changes tended to correlate positively with fear and negatively with euphoria intensity. Procaine-induced visual hallucinations appeared associated with greater global and occipital CBF increases. Absolute occipital CBF increases appeared to correlate positively with visual hallucination intensity. Conclusions: Procaine increased anterior paralimbic CBF, and different clinical responses appeared to be associated with different patterns of CBF changes.

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalArchives of General Psychiatry
Volume53
Issue number1
DOIs
Publication statusPublished - 1996 Jan 1

Fingerprint

Cerebrovascular Circulation
Procaine
Hallucinations
Fear
Cerebral Blood Flow
Emotion
Mediation
Animal Structures
Temporal Lobe
Intravenous Administration
Positron-Emission Tomography

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Ketter, Terence A. ; Andreason, Paul J. ; George, Mark S. ; Lee, Chul Hee ; Gill, Debra S. ; Parekh, Priti Z. ; Willis, Mark W. ; Herscovitch, Peter ; Post, Robert M. / Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. In: Archives of General Psychiatry. 1996 ; Vol. 53, No. 1. pp. 59-69.
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Ketter, TA, Andreason, PJ, George, MS, Lee, CH, Gill, DS, Parekh, PZ, Willis, MW, Herscovitch, P & Post, RM 1996, 'Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences', Archives of General Psychiatry, vol. 53, no. 1, pp. 59-69. https://doi.org/10.1001/archpsyc.1996.01830010061009

Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. / Ketter, Terence A.; Andreason, Paul J.; George, Mark S.; Lee, Chul Hee; Gill, Debra S.; Parekh, Priti Z.; Willis, Mark W.; Herscovitch, Peter; Post, Robert M.

In: Archives of General Psychiatry, Vol. 53, No. 1, 01.01.1996, p. 59-69.

Research output: Contribution to journalArticle

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AU - Andreason, Paul J.

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AU - Parekh, Priti Z.

AU - Willis, Mark W.

AU - Herscovitch, Peter

AU - Post, Robert M.

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N2 - Background: Procaine activates limbic structures in animals. In humans, acute intravenous administration of procaine yields emotional and psychosensory experiences and temporal lobe fast activity. We studied procaine's acute effects on cerebral blood flow (CBF) in relationship to clinical responses. Methods: Cerebral blood flow was assessed by positron emission tomography with oxygen-15-labeled water in 32 healthy volunteers. Data were analyzed with statistical parametric mapping and magnetic resonance imaging-directed regions of interest. Results: Procaine increased global CBF and, to a greater extent, anterior paralimbic CBF. Subjects with intense procaine-induced fear compared with those with euphoria had greater increases in left amygdalar CBF. Absolute and normalized left amygdalar CBF changes tended to correlate positively with fear and negatively with euphoria intensity. Procaine-induced visual hallucinations appeared associated with greater global and occipital CBF increases. Absolute occipital CBF increases appeared to correlate positively with visual hallucination intensity. Conclusions: Procaine increased anterior paralimbic CBF, and different clinical responses appeared to be associated with different patterns of CBF changes.

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