Abstract
Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect on reducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant antibiofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 μg/mL xanthorrhizol for 30 min remained <50% of saliva and multi-species biofilms formed for 24 hr. In addition, exposure to 10 μg/mL xanthorrhizol for 30 min reduced 65 and 77% of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral care functional foods.
| Original language | English |
|---|---|
| Pages (from-to) | 556-560 |
| Number of pages | 5 |
| Journal | Food Science and Biotechnology |
| Volume | 18 |
| Issue number | 2 |
| Publication status | Published - 2009 Apr 18 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
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Anti-biofilm activity of xanthorrhizol isolated from Curcuma xanthorrhiza roxb. against bacterial biofilms formed by saliva and artificial multi-species oral strains. / Yanti; Rukayadi, Yaya; Lee, Kwanhyoung; Han, Sunghwa; Hwang, Jae-Kwan.
In: Food Science and Biotechnology, Vol. 18, No. 2, 18.04.2009, p. 556-560.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anti-biofilm activity of xanthorrhizol isolated from Curcuma xanthorrhiza roxb. against bacterial biofilms formed by saliva and artificial multi-species oral strains
AU - Yanti,
AU - Rukayadi, Yaya
AU - Lee, Kwanhyoung
AU - Han, Sunghwa
AU - Hwang, Jae-Kwan
PY - 2009/4/18
Y1 - 2009/4/18
N2 - Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect on reducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant antibiofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 μg/mL xanthorrhizol for 30 min remained <50% of saliva and multi-species biofilms formed for 24 hr. In addition, exposure to 10 μg/mL xanthorrhizol for 30 min reduced 65 and 77% of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral care functional foods.
AB - Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect on reducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant antibiofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 μg/mL xanthorrhizol for 30 min remained <50% of saliva and multi-species biofilms formed for 24 hr. In addition, exposure to 10 μg/mL xanthorrhizol for 30 min reduced 65 and 77% of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral care functional foods.
UR - http://www.scopus.com/inward/record.url?scp=78650313278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650313278&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 556
EP - 560
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
SN - 1226-7708
IS - 2
ER -