Anti-biofilm activity of xanthorrhizol isolated from Curcuma xanthorrhiza roxb. against bacterial biofilms formed by saliva and artificial multi-species oral strains

Yanti, Yaya Rukayadi, Kwanhyoung Lee, Sunghwa Han, Jae-Kwan Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect on reducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant antibiofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 μg/mL xanthorrhizol for 30 min remained <50% of saliva and multi-species biofilms formed for 24 hr. In addition, exposure to 10 μg/mL xanthorrhizol for 30 min reduced 65 and 77% of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral care functional foods.

Original languageEnglish
Pages (from-to)556-560
Number of pages5
JournalFood Science and Biotechnology
Volume18
Issue number2
Publication statusPublished - 2009 Apr 18

Fingerprint

Curcuma zanthorrhiza
Artificial Saliva
Curcuma
Biofilms
saliva
biofilm
mouth
Saliva
confocal laser scanning microscopy
Confocal Microscopy
Actinomyces viscosus
Streptococcus sanguinis
Streptococcus sanguis
Microbial Viability
Streptococcus mutans
Functional Food
Sesquiterpenes
sesquiterpenoids
functional foods
xanthorrhizol

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

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title = "Anti-biofilm activity of xanthorrhizol isolated from Curcuma xanthorrhiza roxb. against bacterial biofilms formed by saliva and artificial multi-species oral strains",
abstract = "Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect on reducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomyces viscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant antibiofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5 μg/mL xanthorrhizol for 30 min remained <50{\%} of saliva and multi-species biofilms formed for 24 hr. In addition, exposure to 10 μg/mL xanthorrhizol for 30 min reduced 65 and 77{\%} of 24 hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated that xanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C. xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral care functional foods.",
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Anti-biofilm activity of xanthorrhizol isolated from Curcuma xanthorrhiza roxb. against bacterial biofilms formed by saliva and artificial multi-species oral strains. / Yanti; Rukayadi, Yaya; Lee, Kwanhyoung; Han, Sunghwa; Hwang, Jae-Kwan.

In: Food Science and Biotechnology, Vol. 18, No. 2, 18.04.2009, p. 556-560.

Research output: Contribution to journalArticle

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