Anti-diabetic Potential of Silver Nanoparticles Synthesized with Argyreia nervosa Leaf Extract High Synergistic Antibacterial Activity with Standard Antibiotics Against Foodborne Bacteria

Ganesh Dattatraya Saratale, Rijuta Ganesh Saratale, Giovanni Benelli, Gopalakrishnan Kumar, Arivalagan Pugazhendhi, Dong Su Kim, Han Seung Shin

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The current investigation highlighted a novel cost-effective green synthesis of silver nanoparticles (AgNPs) using Argyreia nervosa leaves extract (ANE) as a potential reducing and capping agent. Surface plasmon resonance confirmed the formation of AgNPs with maximum absorbance at λmax = 435 nm. FTIR revealed the involvement of biological macromolecules of ANE in the synthesis and stabilization of AgNPs. HRTEM images showed that the size of the spherical AgNPs ranged between 5 and 40 nm with average particle size of about 15 nm. The ANE-AgNPs showed inhibition activity against carbohydrate digestive enzymes α-amylase and α-glucosidase, with EC50 of 55.5 and 51.7 µg/mL, respectively, indicating its antidiabetic potential. The in vitro antioxidant activity of ANE-AgNPs was evaluated in terms of ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radicals scavenging assays with IC50 value of 44.3 and 55.9 µg/mL, respectively. The AgNPs displayed strong antibacterial activity against foodborne bacteria with zone of inhibition 16.0 and 12.5 mm for Escherichia coli and Staphylococcus aureus, respectively, and also exhibited strong synergistic antibacterial activity together with standard antibiotics. The biological activity in terms of antioxidant, antidiabetic and antibacterial potential could be useful in various bio-applications such as cosmetics, food, and biomedical industry.

Original languageEnglish
Pages (from-to)1709-1727
Number of pages19
JournalJournal of Cluster Science
Volume28
Issue number3
DOIs
Publication statusPublished - 2017 May 1

Bibliographical note

Funding Information:
This research was supported by Agricultural Research Center funded by the Ministry of Food, Forestry, and Fisheries, Korea. Authors are thankful to Prof. Shrikrishna D. Sartale, Savitribai Phule Pune University, India for availing HRTEM facility.

Publisher Copyright:
© 2017, Springer Science+Business Media New York.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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