Anti-diabetic Potential of Silver Nanoparticles Synthesized with Argyreia nervosa Leaf Extract High Synergistic Antibacterial Activity with Standard Antibiotics Against Foodborne Bacteria

Ganesh Dattatraya Saratale, Rijuta Ganesh Saratale, Giovanni Benelli, Gopalakrishnan Kumar, Arivalagan Pugazhendhi, Dong Su Kim, Han Seung Shin

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The current investigation highlighted a novel cost-effective green synthesis of silver nanoparticles (AgNPs) using Argyreia nervosa leaves extract (ANE) as a potential reducing and capping agent. Surface plasmon resonance confirmed the formation of AgNPs with maximum absorbance at λ max  = 435 nm. FTIR revealed the involvement of biological macromolecules of ANE in the synthesis and stabilization of AgNPs. HRTEM images showed that the size of the spherical AgNPs ranged between 5 and 40 nm with average particle size of about 15 nm. The ANE-AgNPs showed inhibition activity against carbohydrate digestive enzymes α-amylase and α-glucosidase, with EC 50 of 55.5 and 51.7 µg/mL, respectively, indicating its antidiabetic potential. The in vitro antioxidant activity of ANE-AgNPs was evaluated in terms of ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radicals scavenging assays with IC 50 value of 44.3 and 55.9 µg/mL, respectively. The AgNPs displayed strong antibacterial activity against foodborne bacteria with zone of inhibition 16.0 and 12.5 mm for Escherichia coli and Staphylococcus aureus, respectively, and also exhibited strong synergistic antibacterial activity together with standard antibiotics. The biological activity in terms of antioxidant, antidiabetic and antibacterial potential could be useful in various bio-applications such as cosmetics, food, and biomedical industry.

Original languageEnglish
Pages (from-to)1709-1727
Number of pages19
JournalJournal of Cluster Science
Volume28
Issue number3
DOIs
Publication statusPublished - 2017 May 1

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antibiotics
Antibiotics
Antioxidants
Silver
Hypoglycemic Agents
Nanoparticles
leaves
bacteria
Bacteria
silver
Glucosidases
Anti-Bacterial Agents
Enzyme inhibition
nanoparticles
Amylases
Sulfonic Acids
Surface Plasmon Resonance
Cosmetics
Food Industry
Reducing Agents

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Saratale, Ganesh Dattatraya ; Saratale, Rijuta Ganesh ; Benelli, Giovanni ; Kumar, Gopalakrishnan ; Pugazhendhi, Arivalagan ; Kim, Dong Su ; Shin, Han Seung. / Anti-diabetic Potential of Silver Nanoparticles Synthesized with Argyreia nervosa Leaf Extract High Synergistic Antibacterial Activity with Standard Antibiotics Against Foodborne Bacteria. In: Journal of Cluster Science. 2017 ; Vol. 28, No. 3. pp. 1709-1727.
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Anti-diabetic Potential of Silver Nanoparticles Synthesized with Argyreia nervosa Leaf Extract High Synergistic Antibacterial Activity with Standard Antibiotics Against Foodborne Bacteria. / Saratale, Ganesh Dattatraya; Saratale, Rijuta Ganesh; Benelli, Giovanni; Kumar, Gopalakrishnan; Pugazhendhi, Arivalagan; Kim, Dong Su; Shin, Han Seung.

In: Journal of Cluster Science, Vol. 28, No. 3, 01.05.2017, p. 1709-1727.

Research output: Contribution to journalArticle

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