Anti-inflammatory effect of licochalcone a via regulation of ORAI1 and K+ channels in T-Lymphocytes

Hong T.L. Phan, Hyun J. Kim, Sungwoo Jo, Woo K. Kim, Wan Namkung, Joo H. Nam

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6 Citations (Scopus)


Calcium signaling plays a vital role in the regulation of various cellular processes, including activation, proliferation, and differentiation of T-lymphocytes, which is mediated by ORAI1 and potassium (K+) channels. These channels have also been identified as highly attractive therapeutic targets for immune-related diseases. Licochalcone A is a licorice-derived chalconoid known for its multifaceted beneficial effects in pharmacological treatments, including its anti-inflammatory, anti-asthmatic, antioxidant, antimicrobial, and antitumorigenic properties. However, its anti-inflamma-tory effects involving ion channels in lymphocytes remain unclear. Thus, the present study aimed to investigate whether licochalcone A inhibits ORAI1 and K+ channels in T-lymphocytes. Our results indicated that licochalcone A suppressed all three channels (ORAI1, Kv1.3, and KCa3.1) in a con-centration-dependent matter, with IC50 values of 2.97 ± 1.217 μM, 0.83 ± 1.222 μM, and 11.21 ± 1.07 μM, respectively. Of note, licochalcone A exerted its suppressive effects on the IL-2 secretion and proliferation in CD3 and CD28 antibody-induced T-cells. These results indicate that the use of lico-chalcone A may provide an effective treatment strategy for inflammation-related immune diseases.

Original languageEnglish
Article number10847
JournalInternational journal of molecular sciences
Issue number19
Publication statusPublished - 2021 Oct 1

Bibliographical note

Funding Information:
Funding: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education of South Korea [Grant number NRF‐2019R1I1A3A01041391 and NRF‐2018R1A6A1A03023718]

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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