Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema

Young Suk Jung, Dae Hwan Kim, Jae Yeon Hwang, Na Young Yun, Yun-Hee Lee, Sang Bae Han, Bang Yeon Hwang, Moon Soon Lee, Heon Sang Jeong, Jin Tae Hong

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Although recent study has shown tricin 4'-O-(threo-β-guaiacylglyceryl) ether (TTGE), an isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the action mechanism has not been fully understood. Here, we examined the effect of TTGE on the inflammation and elucidated the potential mechanism. We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-κB and STAT3. TPA-induced ear edema was also efficiently inhibited by the TTGE treatment. TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-κB and STAT3, which could explain the reduced TPA-induced edema symptoms. Moreover, the introduction of ERK inhibitor abrogated the anti-inflammatory effect of TTGE via the recovery of NF-κB and STAT3 signalings. Taken together, these results suggest that TTGE has anti-inflammatory properties through down-regulation of NF-κB and STAT3 pathways.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalToxicology and Applied Pharmacology
Volume277
Issue number1
DOIs
Publication statusPublished - 2014 May 15

Fingerprint

Flavonolignans
Ether
Ear
Edema
Anti-Inflammatory Agents
Down-Regulation
Inflammation
Recovery
tricin 4'-O-guaiacylglyceryl ether
tricin

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

Jung, Young Suk ; Kim, Dae Hwan ; Hwang, Jae Yeon ; Yun, Na Young ; Lee, Yun-Hee ; Han, Sang Bae ; Hwang, Bang Yeon ; Lee, Moon Soon ; Jeong, Heon Sang ; Hong, Jin Tae. / Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema. In: Toxicology and Applied Pharmacology. 2014 ; Vol. 277, No. 1. pp. 67-76.
@article{4750ffd4ad054601a3dd9319b280a4b3,
title = "Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema",
abstract = "Although recent study has shown tricin 4'-O-(threo-β-guaiacylglyceryl) ether (TTGE), an isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the action mechanism has not been fully understood. Here, we examined the effect of TTGE on the inflammation and elucidated the potential mechanism. We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-κB and STAT3. TPA-induced ear edema was also efficiently inhibited by the TTGE treatment. TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-κB and STAT3, which could explain the reduced TPA-induced edema symptoms. Moreover, the introduction of ERK inhibitor abrogated the anti-inflammatory effect of TTGE via the recovery of NF-κB and STAT3 signalings. Taken together, these results suggest that TTGE has anti-inflammatory properties through down-regulation of NF-κB and STAT3 pathways.",
author = "Jung, {Young Suk} and Kim, {Dae Hwan} and Hwang, {Jae Yeon} and Yun, {Na Young} and Yun-Hee Lee and Han, {Sang Bae} and Hwang, {Bang Yeon} and Lee, {Moon Soon} and Jeong, {Heon Sang} and Hong, {Jin Tae}",
year = "2014",
month = "5",
day = "15",
doi = "10.1016/j.taap.2014.03.001",
language = "English",
volume = "277",
pages = "67--76",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "1",

}

Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema. / Jung, Young Suk; Kim, Dae Hwan; Hwang, Jae Yeon; Yun, Na Young; Lee, Yun-Hee; Han, Sang Bae; Hwang, Bang Yeon; Lee, Moon Soon; Jeong, Heon Sang; Hong, Jin Tae.

In: Toxicology and Applied Pharmacology, Vol. 277, No. 1, 15.05.2014, p. 67-76.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema

AU - Jung, Young Suk

AU - Kim, Dae Hwan

AU - Hwang, Jae Yeon

AU - Yun, Na Young

AU - Lee, Yun-Hee

AU - Han, Sang Bae

AU - Hwang, Bang Yeon

AU - Lee, Moon Soon

AU - Jeong, Heon Sang

AU - Hong, Jin Tae

PY - 2014/5/15

Y1 - 2014/5/15

N2 - Although recent study has shown tricin 4'-O-(threo-β-guaiacylglyceryl) ether (TTGE), an isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the action mechanism has not been fully understood. Here, we examined the effect of TTGE on the inflammation and elucidated the potential mechanism. We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-κB and STAT3. TPA-induced ear edema was also efficiently inhibited by the TTGE treatment. TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-κB and STAT3, which could explain the reduced TPA-induced edema symptoms. Moreover, the introduction of ERK inhibitor abrogated the anti-inflammatory effect of TTGE via the recovery of NF-κB and STAT3 signalings. Taken together, these results suggest that TTGE has anti-inflammatory properties through down-regulation of NF-κB and STAT3 pathways.

AB - Although recent study has shown tricin 4'-O-(threo-β-guaiacylglyceryl) ether (TTGE), an isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the action mechanism has not been fully understood. Here, we examined the effect of TTGE on the inflammation and elucidated the potential mechanism. We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-κB and STAT3. TPA-induced ear edema was also efficiently inhibited by the TTGE treatment. TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-κB and STAT3, which could explain the reduced TPA-induced edema symptoms. Moreover, the introduction of ERK inhibitor abrogated the anti-inflammatory effect of TTGE via the recovery of NF-κB and STAT3 signalings. Taken together, these results suggest that TTGE has anti-inflammatory properties through down-regulation of NF-κB and STAT3 pathways.

UR - http://www.scopus.com/inward/record.url?scp=84897930676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897930676&partnerID=8YFLogxK

U2 - 10.1016/j.taap.2014.03.001

DO - 10.1016/j.taap.2014.03.001

M3 - Article

C2 - 24631338

AN - SCOPUS:84897930676

VL - 277

SP - 67

EP - 76

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 1

ER -