Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema

Young Suk Jung, Dae Hwan Kim, Jae Yeon Hwang, Na Young Yun, Yun Hee Lee, Sang Bae Han, Bang Yeon Hwang, Moon Soon Lee, Heon Sang Jeong, Jin Tae Hong

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although recent study has shown tricin 4'-O-(threo-β-guaiacylglyceryl) ether (TTGE), an isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the action mechanism has not been fully understood. Here, we examined the effect of TTGE on the inflammation and elucidated the potential mechanism. We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-κB and STAT3. TPA-induced ear edema was also efficiently inhibited by the TTGE treatment. TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-κB and STAT3, which could explain the reduced TPA-induced edema symptoms. Moreover, the introduction of ERK inhibitor abrogated the anti-inflammatory effect of TTGE via the recovery of NF-κB and STAT3 signalings. Taken together, these results suggest that TTGE has anti-inflammatory properties through down-regulation of NF-κB and STAT3 pathways.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalToxicology and Applied Pharmacology
Volume277
Issue number1
DOIs
Publication statusPublished - 2014 May 15

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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