Anti-influenza sesquiterpene from the roots of Reynoutria japonica

Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Nguyen Thi Hoai, Ho Viet Duc, Bui Huu Tai, Tran Hong Quang, Hoang Le Tuan Anh, Sang Gu Yeo, Jae Hyoung Song, Doo Sung Cheon, Moon Ho Park, Hyun Jeong Ko, Seung Hyun Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

One new flavonol glycoside, 4′-O-methylmyricitrin 3′-O-β-D-glucopyranoside (1), one new sesquiterpene, reynoudiol (11), as well as the 12 known compounds (2-10, 12-14) quercetin 3-O-methyl ether (2), quercitrin (3), isorhamnetin 3-α-L-rhamnopyranoside (4), tamarixetin 3-α-L-rhamnopyranoside (5), myricitrin (6), 4′-O-methylmyricitrin (7), isorhamnetin 3-O-β-D-xylopyranosyl (1→2)-O-β-D- glucopyranoside (8), isorhamnetin 3-O-β-D-apiofuranosyl-(1→2)-O- β-D-glucopyranoside (9), (+)-catechin (10), 7-drimene-3,11,12-triol (12), clovane-2β,9α-diol (13), and α-cadinol (14), were isolated from the methanol extract of Reynoutria japonica roots. Based on in vitro screening of the anti-influenza activity of the isolated compounds, reynoudiol showed significantly higher activity than that of oseltamivir phosphate at the same concentration, and did not induce any detectable cytopathic effect in MDCK cells. The CC50 of reynoudiol was above 50 μM and could inhibit influenza virus infection with an IC50 of 0.29 ± 0.01 μM. The therapeutic index (TI) of reynoudiol against influenza infection was 172.4, and thus, this compound can be potentially used to treat oseltamivir-resistant influenza virus infection.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalNatural product communications
Volume9
Issue number3
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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  • Cite this

    Nhiem, N. X., Kiem, P. V., Minh, C. V., Hoai, N. T., Duc, H. V., Tai, B. H., Quang, T. H., Anh, H. L. T., Yeo, S. G., Song, J. H., Cheon, D. S., Park, M. H., Ko, H. J., & Kim, S. H. (2014). Anti-influenza sesquiterpene from the roots of Reynoutria japonica. Natural product communications, 9(3), 315-318. https://doi.org/10.1177/1934578x1400900308