Anti-mycobacterial effects of the extract of humulus japonicus

Min Sun Hong, Eun Soon Son, Sung Joong Lee, Sun Kyoung Lee, Ye Jin Lee, Sun Dae Song, Sangnae Cho, Clifton E. Barry, Seok Yong Eum

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalKorean Journal of Food Science and Technology
Volume46
Issue number1
DOIs
Publication statusPublished - 2014 Feb 28

Fingerprint

Humulus
Mycobacterium tuberculosis
extracts
macrophages
antibacterial properties
Macrophages
Butanols
human growth
hops
Hexanes
butanol
Growth
tuberculosis
hexane
Methanol
Culture Media
Humulus japonicus
Tuberculosis
methanol
culture media

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

Hong, M. S., Son, E. S., Lee, S. J., Lee, S. K., Lee, Y. J., Song, S. D., ... Eum, S. Y. (2014). Anti-mycobacterial effects of the extract of humulus japonicus. Korean Journal of Food Science and Technology, 46(1), 94-99. https://doi.org/10.9721/KJFST.2014.46.1.94
Hong, Min Sun ; Son, Eun Soon ; Lee, Sung Joong ; Lee, Sun Kyoung ; Lee, Ye Jin ; Song, Sun Dae ; Cho, Sangnae ; Barry, Clifton E. ; Eum, Seok Yong. / Anti-mycobacterial effects of the extract of humulus japonicus. In: Korean Journal of Food Science and Technology. 2014 ; Vol. 46, No. 1. pp. 94-99.
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Hong, MS, Son, ES, Lee, SJ, Lee, SK, Lee, YJ, Song, SD, Cho, S, Barry, CE & Eum, SY 2014, 'Anti-mycobacterial effects of the extract of humulus japonicus', Korean Journal of Food Science and Technology, vol. 46, no. 1, pp. 94-99. https://doi.org/10.9721/KJFST.2014.46.1.94

Anti-mycobacterial effects of the extract of humulus japonicus. / Hong, Min Sun; Son, Eun Soon; Lee, Sung Joong; Lee, Sun Kyoung; Lee, Ye Jin; Song, Sun Dae; Cho, Sangnae; Barry, Clifton E.; Eum, Seok Yong.

In: Korean Journal of Food Science and Technology, Vol. 46, No. 1, 28.02.2014, p. 94-99.

Research output: Contribution to journalArticle

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