Anti-mycobacterial effects of the extract of humulus japonicus

Min Sun Hong; Eun Soon Son; Sung Joong Lee; Sun Kyoung Lee; Ye Jin Lee; Sun Dae Song; Sang Nae Cho; Clifton E. Barry; Seok Yong Eum

doi:10.9721/KJFST.2014.46.1.94

Anti-mycobacterial effects of the extract of humulus japonicus

Min Sun Hong, Eun Soon Son, Sung Joong Lee, Sun Kyoung Lee, Ye Jin Lee, Sun Dae Song, Sang Nae Cho, Clifton E. Barry, Seok Yong Eum

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Korean Journal of Food Science and Technology
Volume	46
Issue number	1
DOIs	https://doi.org/10.9721/KJFST.2014.46.1.94
Publication status	Published - 2014 Feb 28

All Science Journal Classification (ASJC) codes

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.9721/KJFST.2014.46.1.94

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abstract = "The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.",

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AU - Son, Eun Soon

AU - Lee, Sung Joong

AU - Lee, Sun Kyoung

AU - Lee, Ye Jin

AU - Song, Sun Dae

AU - Cho, Sang Nae

AU - Barry, Clifton E.

AU - Eum, Seok Yong

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AB - The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.

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Anti-mycobacterial effects of the extract of humulus japonicus

Abstract

All Science Journal Classification (ASJC) codes

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