Abstract
The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.
| Original language | English |
|---|---|
| Pages (from-to) | 94-99 |
| Number of pages | 6 |
| Journal | Korean Journal of Food Science and Technology |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Feb 28 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
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Anti-mycobacterial effects of the extract of humulus japonicus. / Hong, Min Sun; Son, Eun Soon; Lee, Sung Joong; Lee, Sun Kyoung; Lee, Ye Jin; Song, Sun Dae; Cho, Sangnae; Barry, Clifton E.; Eum, Seok Yong.
In: Korean Journal of Food Science and Technology, Vol. 46, No. 1, 28.02.2014, p. 94-99.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anti-mycobacterial effects of the extract of humulus japonicus
AU - Hong, Min Sun
AU - Son, Eun Soon
AU - Lee, Sung Joong
AU - Lee, Sun Kyoung
AU - Lee, Ye Jin
AU - Song, Sun Dae
AU - Cho, Sangnae
AU - Barry, Clifton E.
AU - Eum, Seok Yong
PY - 2014/2/28
Y1 - 2014/2/28
N2 - The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.
AB - The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.
UR - http://www.scopus.com/inward/record.url?scp=84896791702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896791702&partnerID=8YFLogxK
U2 - 10.9721/KJFST.2014.46.1.94
DO - 10.9721/KJFST.2014.46.1.94
M3 - Article
AN - SCOPUS:84896791702
VL - 46
SP - 94
EP - 99
JO - Korean Journal of Food Science and Technology
JF - Korean Journal of Food Science and Technology
SN - 0367-6293
IS - 1
ER -