Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice

Manita Dangol, Suyong Kim, Cheng Guo Li, Shayan Fakhraei Lahiji, Mingyu Jang, Yonghao Ma, Inyoung Huh, Hyungil Jung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Natural products such as caffeine have been found to be effective in reducing body weight through lipolysis. Here, we report the successful loading of caffeine onto dissolving microneedle following inhibition of its crystal growth by hyaluronic acid (HA), the matrix material of the dissolving microneedle (DMN). Further, the anti-obesity activity of caffeine was evaluated in high-fat diet-induced obese C57BL/6J mice. After 6 weeks of caffeine loaded dissolving microneedle patch (CMP) administration, lipolysis improved significantly as shown by leptin and adiponectin activity, which resulted in considerable weight loss of about 12.8 ± 0.75% in high-fat diet-induced obese mice. Comparison of the levels of triglyceride, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and low-density lipoprotein (LDL)-cholesterol after CMP administration with the initial levels in obese mice indicated significant anti-obesity activity of CMP. These findings suggested that a novel CMP with an increased amount of caffeine loaded onto DMN has therapeutic activity against obesity.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalJournal of Controlled Release
Volume265
DOIs
Publication statusPublished - 2017 Nov 10

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Obese Mice
High Fat Diet
Cytidine Monophosphate
Caffeine
Inbred C57BL Mouse
Obesity
Lipolysis
Adiponectin
Hyaluronic Acid
Leptin
Crystallization
Biological Products
LDL Cholesterol
HDL Cholesterol
Weight Loss
Triglycerides
Cholesterol
Body Weight

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Dangol, Manita ; Kim, Suyong ; Li, Cheng Guo ; Fakhraei Lahiji, Shayan ; Jang, Mingyu ; Ma, Yonghao ; Huh, Inyoung ; Jung, Hyungil. / Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice. In: Journal of Controlled Release. 2017 ; Vol. 265. pp. 41-47.
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Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice. / Dangol, Manita; Kim, Suyong; Li, Cheng Guo; Fakhraei Lahiji, Shayan; Jang, Mingyu; Ma, Yonghao; Huh, Inyoung; Jung, Hyungil.

In: Journal of Controlled Release, Vol. 265, 10.11.2017, p. 41-47.

Research output: Contribution to journalArticle

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