Anti-obesity effect of alkaline reduced water in high fat-fed obese mice

Rosa Mistica Coles Ignacio, Tae Young Kang, Cheol Su Kim, Soo Ki Kim, Young Chul Yang, Joon Hyung Sohn, Kyu Jae Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.

Original languageEnglish
Pages (from-to)1052-1059
Number of pages8
JournalBiological and Pharmaceutical Bulletin
Volume36
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Obese Mice
Obesity
Fats
Water
High Fat Diet
Adiposity
Liver
Adipokines
Adiponectin
Leptin
Inbred C57BL Mouse
Cytochrome P-450 Enzyme System
Drinking
Weight Gain
Cholesterol
Body Weight
Cytokines
Diet
Messenger RNA
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Ignacio, R. M. C., Kang, T. Y., Kim, C. S., Kim, S. K., Yang, Y. C., Sohn, J. H., & Lee, K. J. (2013). Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biological and Pharmaceutical Bulletin, 36(7), 1052-1059. https://doi.org/10.1248/bpb.b12-00781
Ignacio, Rosa Mistica Coles ; Kang, Tae Young ; Kim, Cheol Su ; Kim, Soo Ki ; Yang, Young Chul ; Sohn, Joon Hyung ; Lee, Kyu Jae. / Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. In: Biological and Pharmaceutical Bulletin. 2013 ; Vol. 36, No. 7. pp. 1052-1059.
@article{240dcbfd51ed417f8b5ff55947189fb7,
title = "Anti-obesity effect of alkaline reduced water in high fat-fed obese mice",
abstract = "Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45{\%} fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.",
author = "Ignacio, {Rosa Mistica Coles} and Kang, {Tae Young} and Kim, {Cheol Su} and Kim, {Soo Ki} and Yang, {Young Chul} and Sohn, {Joon Hyung} and Lee, {Kyu Jae}",
year = "2013",
month = "7",
day = "1",
doi = "10.1248/bpb.b12-00781",
language = "English",
volume = "36",
pages = "1052--1059",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "7",

}

Ignacio, RMC, Kang, TY, Kim, CS, Kim, SK, Yang, YC, Sohn, JH & Lee, KJ 2013, 'Anti-obesity effect of alkaline reduced water in high fat-fed obese mice', Biological and Pharmaceutical Bulletin, vol. 36, no. 7, pp. 1052-1059. https://doi.org/10.1248/bpb.b12-00781

Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. / Ignacio, Rosa Mistica Coles; Kang, Tae Young; Kim, Cheol Su; Kim, Soo Ki; Yang, Young Chul; Sohn, Joon Hyung; Lee, Kyu Jae.

In: Biological and Pharmaceutical Bulletin, Vol. 36, No. 7, 01.07.2013, p. 1052-1059.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-obesity effect of alkaline reduced water in high fat-fed obese mice

AU - Ignacio, Rosa Mistica Coles

AU - Kang, Tae Young

AU - Kim, Cheol Su

AU - Kim, Soo Ki

AU - Yang, Young Chul

AU - Sohn, Joon Hyung

AU - Lee, Kyu Jae

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.

AB - Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.

UR - http://www.scopus.com/inward/record.url?scp=84880417830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880417830&partnerID=8YFLogxK

U2 - 10.1248/bpb.b12-00781

DO - 10.1248/bpb.b12-00781

M3 - Article

C2 - 23811554

AN - SCOPUS:84880417830

VL - 36

SP - 1052

EP - 1059

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 7

ER -