Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

So Hyung Hong, Ki Tae Suk, Sang Hyeon Choi, Jung Wook Lee, Ho Taik Sung, Chang Hoon Kim, Eun Ji Kim, Myoung Jo Kim, Sang Hak Han, Moonyoung Kim, Soonkoo Baik, Dong Joon Kim, Gyoung Ja Lee, Sang kyu Lee, Seung Ha Park, Ohk Hyun Ryu

Research output: Contribution to journalArticle

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Abstract

Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalFood and Chemical Toxicology
Volume55
DOIs
Publication statusPublished - 2013 May 1

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Toxicodendron vernicifluum
Rhus
Panax ginseng
Panax
fatty liver
natural killer cells
Oxidants
oxidants
Natural Killer Cells
Liver
Inbred OLETF Rats
Rats
ursodeoxycholic acid
rats
Ursodeoxycholic Acid
Diet
Lipids
Nutrition
liver
Neutrophil Infiltration

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Hong, So Hyung ; Suk, Ki Tae ; Choi, Sang Hyeon ; Lee, Jung Wook ; Sung, Ho Taik ; Kim, Chang Hoon ; Kim, Eun Ji ; Kim, Myoung Jo ; Han, Sang Hak ; Kim, Moonyoung ; Baik, Soonkoo ; Kim, Dong Joon ; Lee, Gyoung Ja ; Lee, Sang kyu ; Park, Seung Ha ; Ryu, Ohk Hyun. / Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat. In: Food and Chemical Toxicology. 2013 ; Vol. 55. pp. 586-591.
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abstract = "Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.",
author = "Hong, {So Hyung} and Suk, {Ki Tae} and Choi, {Sang Hyeon} and Lee, {Jung Wook} and Sung, {Ho Taik} and Kim, {Chang Hoon} and Kim, {Eun Ji} and Kim, {Myoung Jo} and Han, {Sang Hak} and Moonyoung Kim and Soonkoo Baik and Kim, {Dong Joon} and Lee, {Gyoung Ja} and Lee, {Sang kyu} and Park, {Seung Ha} and Ryu, {Ohk Hyun}",
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Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat. / Hong, So Hyung; Suk, Ki Tae; Choi, Sang Hyeon; Lee, Jung Wook; Sung, Ho Taik; Kim, Chang Hoon; Kim, Eun Ji; Kim, Myoung Jo; Han, Sang Hak; Kim, Moonyoung; Baik, Soonkoo; Kim, Dong Joon; Lee, Gyoung Ja; Lee, Sang kyu; Park, Seung Ha; Ryu, Ohk Hyun.

In: Food and Chemical Toxicology, Vol. 55, 01.05.2013, p. 586-591.

Research output: Contribution to journalArticle

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T1 - Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

AU - Hong, So Hyung

AU - Suk, Ki Tae

AU - Choi, Sang Hyeon

AU - Lee, Jung Wook

AU - Sung, Ho Taik

AU - Kim, Chang Hoon

AU - Kim, Eun Ji

AU - Kim, Myoung Jo

AU - Han, Sang Hak

AU - Kim, Moonyoung

AU - Baik, Soonkoo

AU - Kim, Dong Joon

AU - Lee, Gyoung Ja

AU - Lee, Sang kyu

AU - Park, Seung Ha

AU - Ryu, Ohk Hyun

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N2 - Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

AB - Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

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