Anti-p200 pemphigoid

Myung Hoon Lee, Ji Young Yoo, Moo Kyu Suh, Tae Jung Jang, Soo Chan Kim

Research output: Contribution to journalArticle

Abstract

Anti-p200 pemphigoid is an autoimmune subepidermal bullous disease characterized by circulating and tissue-bound autoantibodies directed against a 200 kD protein of the human dermis. We report a 78-year-old male who was presented with bullous eruptions on the trunk, extremities, which clinically resemble bullous pemphigoid, epidermolysis bullosa aquisita, linear IgA dermatosis or dermatitis herpetiformis. Oral muscosa of the lower lip was also affected. Histopathological examination of a skin biopsy specimen from the trunk revealed subepidermal blister and infiltration predominantly by neutrophils. Direct immunofluorescence revealed linear deposits of IgG, C3 and IgA at the basement membrane zone. Indirect immunofluorescence using salt-split skin showed that IgG antibodies bound on the dermal side. Immunoblotting with dermal extracts showed that the patient's IgG autoantibodies reacted with a 200 kD protein. The patient showed good response to dapsone.

Original languageEnglish
Pages (from-to)912-916
Number of pages5
JournalKorean Journal of Dermatology
Volume50
Issue number10
Publication statusPublished - 2012 Oct

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Lee, M. H., Yoo, J. Y., Suh, M. K., Jang, T. J., & Kim, S. C. (2012). Anti-p200 pemphigoid. Korean Journal of Dermatology, 50(10), 912-916.