Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)

Sunghwa Han, Jae-Kwan Hwang, Kwang Kyun Park, WonYoon Chung, Sang Kook Lee, Jaekyung Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.

Original languageEnglish
Pages (from-to)1667-1671
Number of pages5
JournalFood Science and Biotechnology
Volume19
Issue number6
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

photoaging
Pyrazines
pyrazines
Prunus persica
peaches
interstitial collagenase
Matrix Metalloproteinase 1
Collagen Type I
Antioxidants
antioxidants
Butanols
butanol
skin (animal)
biphenyl
fibroblasts
Western blotting
Ethanol
Fibroblasts
Western Blotting
polymerase chain reaction

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

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title = "Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)",
abstract = "In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95{\%} ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.",
author = "Sunghwa Han and Jae-Kwan Hwang and Park, {Kwang Kyun} and WonYoon Chung and Lee, {Sang Kook} and Jaekyung Kim",
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Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch). / Han, Sunghwa; Hwang, Jae-Kwan; Park, Kwang Kyun; Chung, WonYoon; Lee, Sang Kook; Kim, Jaekyung.

In: Food Science and Biotechnology, Vol. 19, No. 6, 01.01.2010, p. 1667-1671.

Research output: Contribution to journalArticle

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