Anti-proliferative effect of licochalcone A on vascular smooth muscle cells

Jin Hee Park, Hyun Joung Lim, Kuy Sook Lee, Seahyoung Lee, Hyun Jeong Kwak, Jeong Heon Cha, Hyun Young Park

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 μM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.

Original languageEnglish
Pages (from-to)1996-2000
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume31
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1

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Vascular Smooth Muscle
Smooth Muscle Myocytes
Platelet-Derived Growth Factor
Cell Proliferation
Glycyrrhiza
Phosphorylation
Cyclin A
Mitogen-Activated Protein Kinase 3
licochalcone A
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase 1
Cyclin D1
Cell Cycle Checkpoints
S Phase
Flavonoids
Cell Cycle
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Park, Jin Hee ; Lim, Hyun Joung ; Lee, Kuy Sook ; Lee, Seahyoung ; Kwak, Hyun Jeong ; Cha, Jeong Heon ; Park, Hyun Young. / Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. In: Biological and Pharmaceutical Bulletin. 2008 ; Vol. 31, No. 11. pp. 1996-2000.
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abstract = "Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 μM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.",
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Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. / Park, Jin Hee; Lim, Hyun Joung; Lee, Kuy Sook; Lee, Seahyoung; Kwak, Hyun Jeong; Cha, Jeong Heon; Park, Hyun Young.

In: Biological and Pharmaceutical Bulletin, Vol. 31, No. 11, 01.11.2008, p. 1996-2000.

Research output: Contribution to journalArticle

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AU - Cha, Jeong Heon

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AB - Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 μM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.

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