Anti-tumor activity of benzylideneacetophenone derivatives via proteasomal inhibition in prostate cancer cells

Yun Hee Lee, Jaesuk Yun, Jae Chul Jung, Seikwan Oh, Young Suk Jung

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3 Citations (Scopus)

Abstract

A number of some chalcone derivatives possess promising biological properties including anti-inflammation, anti-oxidant, and anti-tumor activity. Although it has been shown that some derivatives of chalcone induce apoptosis in different kinds of cancer cells, the involved mechanism of action is not well defined. The purpose of this study is to investigate the primary target of a benzylideneacetophenone derivative (JC3), which is a synthetic compound derived from the chalcone family, in human cancer, using prostate cancer cells as a working model. Herein, we show that JC3 inhibits proteasomal activity as indicated by both in vitro and in cell-based assays. Especially, the JC3-dimer was more potent than monomer in the aspect of proteasome inhibition, which induced apoptosis significantly in the prostate cancer cells. Owing to the critical roles of the proteasome in the biology of human tumor progression, invasion, and metastasis, these findings give an important clue for the development of novel anti-tumor agents.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalPharmazie
Volume71
Issue number5
DOIs
Publication statusPublished - 2016 May

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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