Antiallergic activity profile in vitro RBL-2H3 and in vivo passive cutaneous anaphylaxis mouse model of new sila-substituted 1,3,4-oxadiazoles

Guda Dinneswara Reddy, Sae Jin Park, Hyeon Mo Cho, Tack Joong Kim, Myong Euy Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model and the in vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, and also suppressed the expression of TNF-α mRNA and Akt phosphorylation in antigen-stimulated RBL-2H3 cells. We also studied the effect of 5c in an in vivo passive cutaneous anaphylaxis (PCA) mouse model. The suppression by 5c was more effective than that by diphenylhydramine (DPH), a typical anti-histamine drug.

Original languageEnglish
Pages (from-to)6438-6444
Number of pages7
JournalJournal of Medicinal Chemistry
Volume55
Issue number14
DOIs
Publication statusPublished - 2012 Jul 26

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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