Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume

Ki Suk Jeon; Hee Jun Na; Young Myeong Kim; Ho Jeong Kwon

doi:10.1016/j.bbrc.2005.03.109

Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume

Ki Suk Jeon, Hee Jun Na, Young Myeong Kim, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.

Original language	English
Pages (from-to)	1268-1274
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	330
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.03.109
Publication status	Published - 2005 May 20

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Laboratory (2004-02405) and the Brain Korea 21 project (C049).

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2005.03.109

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title = "Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume",

abstract = "Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.",

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AU - Na, Hee Jun

AU - Kim, Young Myeong

AU - Kwon, Ho Jeong

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Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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