Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume

Ki Suk Jeon, Hee Jun Na, Young Myeong Kim, Ho Jeong Kwon

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.

Original languageEnglish
Pages (from-to)1268-1274
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume330
Issue number4
DOIs
Publication statusPublished - 2005 May 20

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Canavalia
Endothelial cells
Fabaceae
Angiogenesis Inhibitors
Endothelial Cells
Vascular Endothelial Growth Factor A
Cell growth
Fibroblast Growth Factor 2
Intercellular Signaling Peptides and Proteins
Reactive Oxygen Species
Seeds
Cytotoxicity
Seed
Growth
3,5-dihydroxy-4-methoxybenzoic acid
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.",
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Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume. / Jeon, Ki Suk; Na, Hee Jun; Kim, Young Myeong; Kwon, Ho Jeong.

In: Biochemical and Biophysical Research Communications, Vol. 330, No. 4, 20.05.2005, p. 1268-1274.

Research output: Contribution to journalArticle

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