Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane

Mankil Jung; Jungae Tak; Won Yoon Chung; Kwang Kyun Park

doi:10.1016/j.bmcl.2005.11.074

Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane

Mankil Jung, Jungae Tak, Won Yoon Chung, Kwang Kyun Park

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Non acetal-type derivatives at C-12 of artemisinin and their novel dimers including a fullerene conjugate were synthesized and some of them showed potent in vivo antiangiogenic activity on chorioallantoic membrane higher than or comparable to those of fumagillin and thalidomide.

Original language	English
Pages (from-to)	1227-1230
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.074
Publication status	Published - 2006 Mar 1

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2003-015-C00380). We express our thanks to CKD Corp. for providing fumagillin.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane",

abstract = "Non acetal-type derivatives at C-12 of artemisinin and their novel dimers including a fullerene conjugate were synthesized and some of them showed potent in vivo antiangiogenic activity on chorioallantoic membrane higher than or comparable to those of fumagillin and thalidomide.",

author = "Mankil Jung and Jungae Tak and Chung, {Won Yoon} and Park, {Kwang Kyun}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2003-015-C00380). We express our thanks to CKD Corp. for providing fumagillin. ",

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N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2003-015-C00380). We express our thanks to CKD Corp. for providing fumagillin.

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