Non acetal-type derivatives at C-12 of artemisinin and their novel dimers including a fullerene conjugate were synthesized and some of them showed potent in vivo antiangiogenic activity on chorioallantoic membrane higher than or comparable to those of fumagillin and thalidomide.
Bibliographical noteFunding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2003-015-C00380). We express our thanks to CKD Corp. for providing fumagillin.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry