Antibacterial activity of panduratin a and isopanduratin a isolated from Kaempferia pandurata Roxb. against acne-causing microorganisms

Min Soo Song, Jae Seok Shim, Song Hui Gwon, Chan Woo Lee, Han Sung Kim, Jae Kwan Hwang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Propionibacterium acnes is the predominant organism in sebaceous regions of the skin and is thought to play an important role in the pathogenesis of inflamed lesions. Antibacterial compounds against P acnes were isolated from the ethanol extract of Kaempferia pandurata Roxb. and identified as panduratin A and isopanduratin A. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of panduratin A for P acnes were 2 and 4 μg/mL, respectively, while those of isopanduratin A were 4 and 8 μg/mL, respectively. The time-dependent killing effect showed that panduratin A and isopanduratin A completely inhibited the growth of P acnes at 4 and 8 μg/mL in 48 hr, respectively. Panduratin A and isopanduratin A demonstrated high antibacterial activities not only against P acnes but also other skin microorganisms. The results suggest that panduratin A and isopanduratin A could be employed as natural antibacterial agents to inhibit the growth of acne and skin disease causing microorganisms.

Original languageEnglish
Pages (from-to)1357-1360
Number of pages4
JournalFood Science and Biotechnology
Volume17
Issue number6
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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