Propionibacterium acnes is the predominant organism in sebaceous regions of the skin and is thought to play an important role in the pathogenesis of inflamed lesions. Antibacterial compounds against P acnes were isolated from the ethanol extract of Kaempferia pandurata Roxb. and identified as panduratin A and isopanduratin A. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of panduratin A for P acnes were 2 and 4 μg/mL, respectively, while those of isopanduratin A were 4 and 8 μg/mL, respectively. The time-dependent killing effect showed that panduratin A and isopanduratin A completely inhibited the growth of P acnes at 4 and 8 μg/mL in 48 hr, respectively. Panduratin A and isopanduratin A demonstrated high antibacterial activities not only against P acnes but also other skin microorganisms. The results suggest that panduratin A and isopanduratin A could be employed as natural antibacterial agents to inhibit the growth of acne and skin disease causing microorganisms.
|Number of pages||4|
|Journal||Food Science and Biotechnology|
|Publication status||Published - 2008 Dec 1|
All Science Journal Classification (ASJC) codes
- Food Science
- Applied Microbiology and Biotechnology