Antibacterial and sporicidal activity of macelignan isolated from nutmeg (Myristica fragrans Houtt.) against Bacillus cereus

Yaya Rukayadi, Kwanhyoung Lee, Sunghwa Han, Sungkyung Kim, Jae Kwan Hwang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Macelignan is a bioactive compound isolated from nutmeg (Myristica fragrans Houtt.) which has been traditionally used for the food and pharmaceutical purposes. In this study, the activities of macelignan against vegetative cells and spores of Bacillus cereus were evaluated in vitro. Our results showed that the vegetative cells of B. cereus were significantly inhibited in growth by macelignan with minimum inhibitory concentration (MIC) of 4 μg/mL. The vegetative cells of B. cereus were completely killed with minimum bactericidal concentration (MBC) of 8 μg/mL of macelignan. Killing time of macelignan against vegetative cells of B. cereus was very fast; endpoint of macelignan was reached after 4 hr of incubation at 4×MIC. Macelignan inactivated more than 3-log (99.9%) of spores/mL of B. cereus at the concentration of 100 μg/mL. Macelignan was found to be effective against vegetative cells and spores of B. cereus. These results suggest that macelignan might be good to be developed as a food preservative.

Original languageEnglish
Pages (from-to)1301-1304
Number of pages4
JournalFood Science and Biotechnology
Volume18
Issue number5
Publication statusPublished - 2009 Oct 1

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Myristica fragrans
nutmeg
Bacillus cereus
vegetative cells
spores
Spores
food preservatives
minimum inhibitory concentration
endpoints
Food Preservatives
macelignan
Microbial Sensitivity Tests
drugs

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

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abstract = "Macelignan is a bioactive compound isolated from nutmeg (Myristica fragrans Houtt.) which has been traditionally used for the food and pharmaceutical purposes. In this study, the activities of macelignan against vegetative cells and spores of Bacillus cereus were evaluated in vitro. Our results showed that the vegetative cells of B. cereus were significantly inhibited in growth by macelignan with minimum inhibitory concentration (MIC) of 4 μg/mL. The vegetative cells of B. cereus were completely killed with minimum bactericidal concentration (MBC) of 8 μg/mL of macelignan. Killing time of macelignan against vegetative cells of B. cereus was very fast; endpoint of macelignan was reached after 4 hr of incubation at 4×MIC. Macelignan inactivated more than 3-log (99.9{\%}) of spores/mL of B. cereus at the concentration of 100 μg/mL. Macelignan was found to be effective against vegetative cells and spores of B. cereus. These results suggest that macelignan might be good to be developed as a food preservative.",
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Antibacterial and sporicidal activity of macelignan isolated from nutmeg (Myristica fragrans Houtt.) against Bacillus cereus. / Rukayadi, Yaya; Lee, Kwanhyoung; Han, Sunghwa; Kim, Sungkyung; Hwang, Jae Kwan.

In: Food Science and Biotechnology, Vol. 18, No. 5, 01.10.2009, p. 1301-1304.

Research output: Contribution to journalArticle

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