Antibacterial behaviour of quaternized poly(vinyl chloride)-g-poly(4-vinyl pyridine) graft copolymers

Madhumita Patel, Rajkumar Patel, Won Seok Chi, Jong Hak Kim, Jung Suk Sung

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11 Citations (Scopus)


Amphiphilic graft copolymers consisting of poly(vinyl chloride) (PVC) main chains and poly(4-vinyl pyridine) (P4VP) side chains were synthesized via atom transfer radical polymerization (ATRP) using direct initiation of chlorine atoms. The successful synthesis of PVC-g-P4VP graft copolymers was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis showed that PVC-g-P4VP exhibited microphase-separated, ordered structure with 37.6 nm of domain spacing, which was not observed in neat PVC. For antibacterial applications, the tertiary nitrogen atoms of PVC-g-P4VP was quaternized using 1-bromohexane, as confirmed by FTIR measurements. Bacteria including Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus), and Pseudomonas aeruginosa (P. aeruginosa) were completely killed in 24 h on the quaternized PVC-g-P4VP (46% grafting) surface, indicating its excellent antibacterial behavior while it showed to be cytotoxic to mammalian cell.

Original languageEnglish
Pages (from-to)265-274
Number of pages10
JournalChinese Journal of Polymer Science (English Edition)
Issue number2
Publication statusPublished - 2015 Feb

Bibliographical note

Publisher Copyright:
© 2015, Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg.

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics

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