Abstract
The main objective of this study was to manufacture an oral rinse using the natural antibacterial agent (phytosphingosine, Doosan, Korea) for the prevention of periodontal disease and dental caries. Phytosphingosine is known to inhibit the growth of bacterial strains and induce apoptotic cell death in human cancer lines. In this study, antibacterial activity and cytotoxicity of oral rinses were performed with an experimental group containing phytosphingosine(PS) in vitro. Control groups consist of two Korean products and two American products containing chlorhexidine and cetylpyridinium chloride, respectively. There was no significant difference between experimental and control groups in the antibacterial activity and cytotoxicity except for Chika Chika Liq (p<0.05). According to the results, antibacterial activity of oral rinse containing PS was 99.62%, the strongest contact inhibition of Streptococcus mutons strain among tested groups. In the cytotoxicity test of oral rinses, PS had a weaker cytotoxicity than control groups in mouse and human normal cell lines and showed the strongest cytotoxicity in human oral cancer cell lines (KB cell). From the results, PS may be widely used as an oral rinse for the healthy and the patients with oral cancers in the near future.
| Original language | English |
|---|---|
| Pages (from-to) | 941-944 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| Publication status | Published - 2007 Apr 16 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
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Antibacterial effect of oral rinses containing phytosphingosine. / Oh, S. H.; Choi, M. J.; Kim, B. I.; Kim, K. M.; Kim, K. N.
In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 941-944.Research output: Contribution to journal › Article
TY - JOUR
T1 - Antibacterial effect of oral rinses containing phytosphingosine
AU - Oh, S. H.
AU - Choi, M. J.
AU - Kim, B. I.
AU - Kim, K. M.
AU - Kim, K. N.
PY - 2007/4/16
Y1 - 2007/4/16
N2 - The main objective of this study was to manufacture an oral rinse using the natural antibacterial agent (phytosphingosine, Doosan, Korea) for the prevention of periodontal disease and dental caries. Phytosphingosine is known to inhibit the growth of bacterial strains and induce apoptotic cell death in human cancer lines. In this study, antibacterial activity and cytotoxicity of oral rinses were performed with an experimental group containing phytosphingosine(PS) in vitro. Control groups consist of two Korean products and two American products containing chlorhexidine and cetylpyridinium chloride, respectively. There was no significant difference between experimental and control groups in the antibacterial activity and cytotoxicity except for Chika Chika Liq (p<0.05). According to the results, antibacterial activity of oral rinse containing PS was 99.62%, the strongest contact inhibition of Streptococcus mutons strain among tested groups. In the cytotoxicity test of oral rinses, PS had a weaker cytotoxicity than control groups in mouse and human normal cell lines and showed the strongest cytotoxicity in human oral cancer cell lines (KB cell). From the results, PS may be widely used as an oral rinse for the healthy and the patients with oral cancers in the near future.
AB - The main objective of this study was to manufacture an oral rinse using the natural antibacterial agent (phytosphingosine, Doosan, Korea) for the prevention of periodontal disease and dental caries. Phytosphingosine is known to inhibit the growth of bacterial strains and induce apoptotic cell death in human cancer lines. In this study, antibacterial activity and cytotoxicity of oral rinses were performed with an experimental group containing phytosphingosine(PS) in vitro. Control groups consist of two Korean products and two American products containing chlorhexidine and cetylpyridinium chloride, respectively. There was no significant difference between experimental and control groups in the antibacterial activity and cytotoxicity except for Chika Chika Liq (p<0.05). According to the results, antibacterial activity of oral rinse containing PS was 99.62%, the strongest contact inhibition of Streptococcus mutons strain among tested groups. In the cytotoxicity test of oral rinses, PS had a weaker cytotoxicity than control groups in mouse and human normal cell lines and showed the strongest cytotoxicity in human oral cancer cell lines (KB cell). From the results, PS may be widely used as an oral rinse for the healthy and the patients with oral cancers in the near future.
UR - http://www.scopus.com/inward/record.url?scp=34147124474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147124474&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:34147124474
VL - 342-343
SP - 941
EP - 944
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -