Antibacterial effects of the urushiol component in the sap of the lacquer tree (Rhus verniciflua stokes) on Helicobacter pylori

Ki Tae Suk, Soon Koo Baik, Hyun Soo Kim, Su Min Park, Ki Jung Paeng, Young Uh, In Ho Jang, Mee Yon Cho, Eung Ho Choi, Myong Jo Kim, Young Lim Ham

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Urushiol is a major component of the lacquer tree which has been used as a folk remedy for the relief of abdominal discomfort in Korea. The aim of this study was to evaluate the antibacterial effects of the urushiol on Helicobacter pylori. Materials and Methods: Monomer and 2-4 polymer urushiol were used. In the in vitro study, pH- and concentration-dependent antibacterial activity of the urushiol against H. pylori were investigated. In addition, the serial morphological effects of urushiol on H. pylori were examined by electron microscopy. In vivo animal study was performed for the safety, eradication rate, and the effect on gastritis of urushiol. The expression of pro-inflammatory cytokines was checked. Results: All strains survived within a pH 6.0-9.0. The minimal inhibitory concentrations of the extract against strains ranged 0.064-0.256mg/mL. Urushiol caused separation of the membrane and lysis of H. pylori within 10 minutes. Urushiol (0.128mg/mL×7days) did not cause complications on mice. The eradication rates were 33% in the urushiol monotherapy, 75% in the triple therapy (omeprazole+clarithromycin+metronidazole), and 100% in the urushiol+triple therapy, respectively. H. pylori-induced gastritis was not changed by urushiol but reduced by eradication. Only the expression of interleukin-1β in the gastric tissue was significantly increased by H. pylori infection and reduced by the urushiol and H. pylori eradication (p = .014). Conclusions: The urushiol has an antibacterial effect against H. pylori infection and can be used safely for H. pylori eradication in a mouse model.

Original languageEnglish
Pages (from-to)434-443
Number of pages10
JournalHelicobacter
Volume16
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Rhus
Lacquer
Helicobacter pylori
Helicobacter Infections
Gastritis
urushiol
Clarithromycin
Omeprazole
Metronidazole
Traditional Medicine
Korea
Interleukin-1

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Infectious Diseases

Cite this

Suk, Ki Tae ; Baik, Soon Koo ; Kim, Hyun Soo ; Park, Su Min ; Paeng, Ki Jung ; Uh, Young ; Jang, In Ho ; Cho, Mee Yon ; Choi, Eung Ho ; Kim, Myong Jo ; Ham, Young Lim. / Antibacterial effects of the urushiol component in the sap of the lacquer tree (Rhus verniciflua stokes) on Helicobacter pylori. In: Helicobacter. 2011 ; Vol. 16, No. 6. pp. 434-443.
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abstract = "Background: Urushiol is a major component of the lacquer tree which has been used as a folk remedy for the relief of abdominal discomfort in Korea. The aim of this study was to evaluate the antibacterial effects of the urushiol on Helicobacter pylori. Materials and Methods: Monomer and 2-4 polymer urushiol were used. In the in vitro study, pH- and concentration-dependent antibacterial activity of the urushiol against H. pylori were investigated. In addition, the serial morphological effects of urushiol on H. pylori were examined by electron microscopy. In vivo animal study was performed for the safety, eradication rate, and the effect on gastritis of urushiol. The expression of pro-inflammatory cytokines was checked. Results: All strains survived within a pH 6.0-9.0. The minimal inhibitory concentrations of the extract against strains ranged 0.064-0.256mg/mL. Urushiol caused separation of the membrane and lysis of H. pylori within 10 minutes. Urushiol (0.128mg/mL×7days) did not cause complications on mice. The eradication rates were 33{\%} in the urushiol monotherapy, 75{\%} in the triple therapy (omeprazole+clarithromycin+metronidazole), and 100{\%} in the urushiol+triple therapy, respectively. H. pylori-induced gastritis was not changed by urushiol but reduced by eradication. Only the expression of interleukin-1β in the gastric tissue was significantly increased by H. pylori infection and reduced by the urushiol and H. pylori eradication (p = .014). Conclusions: The urushiol has an antibacterial effect against H. pylori infection and can be used safely for H. pylori eradication in a mouse model.",
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Antibacterial effects of the urushiol component in the sap of the lacquer tree (Rhus verniciflua stokes) on Helicobacter pylori. / Suk, Ki Tae; Baik, Soon Koo; Kim, Hyun Soo; Park, Su Min; Paeng, Ki Jung; Uh, Young; Jang, In Ho; Cho, Mee Yon; Choi, Eung Ho; Kim, Myong Jo; Ham, Young Lim.

In: Helicobacter, Vol. 16, No. 6, 01.12.2011, p. 434-443.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antibacterial effects of the urushiol component in the sap of the lacquer tree (Rhus verniciflua stokes) on Helicobacter pylori

AU - Suk, Ki Tae

AU - Baik, Soon Koo

AU - Kim, Hyun Soo

AU - Park, Su Min

AU - Paeng, Ki Jung

AU - Uh, Young

AU - Jang, In Ho

AU - Cho, Mee Yon

AU - Choi, Eung Ho

AU - Kim, Myong Jo

AU - Ham, Young Lim

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: Urushiol is a major component of the lacquer tree which has been used as a folk remedy for the relief of abdominal discomfort in Korea. The aim of this study was to evaluate the antibacterial effects of the urushiol on Helicobacter pylori. Materials and Methods: Monomer and 2-4 polymer urushiol were used. In the in vitro study, pH- and concentration-dependent antibacterial activity of the urushiol against H. pylori were investigated. In addition, the serial morphological effects of urushiol on H. pylori were examined by electron microscopy. In vivo animal study was performed for the safety, eradication rate, and the effect on gastritis of urushiol. The expression of pro-inflammatory cytokines was checked. Results: All strains survived within a pH 6.0-9.0. The minimal inhibitory concentrations of the extract against strains ranged 0.064-0.256mg/mL. Urushiol caused separation of the membrane and lysis of H. pylori within 10 minutes. Urushiol (0.128mg/mL×7days) did not cause complications on mice. The eradication rates were 33% in the urushiol monotherapy, 75% in the triple therapy (omeprazole+clarithromycin+metronidazole), and 100% in the urushiol+triple therapy, respectively. H. pylori-induced gastritis was not changed by urushiol but reduced by eradication. Only the expression of interleukin-1β in the gastric tissue was significantly increased by H. pylori infection and reduced by the urushiol and H. pylori eradication (p = .014). Conclusions: The urushiol has an antibacterial effect against H. pylori infection and can be used safely for H. pylori eradication in a mouse model.

AB - Background: Urushiol is a major component of the lacquer tree which has been used as a folk remedy for the relief of abdominal discomfort in Korea. The aim of this study was to evaluate the antibacterial effects of the urushiol on Helicobacter pylori. Materials and Methods: Monomer and 2-4 polymer urushiol were used. In the in vitro study, pH- and concentration-dependent antibacterial activity of the urushiol against H. pylori were investigated. In addition, the serial morphological effects of urushiol on H. pylori were examined by electron microscopy. In vivo animal study was performed for the safety, eradication rate, and the effect on gastritis of urushiol. The expression of pro-inflammatory cytokines was checked. Results: All strains survived within a pH 6.0-9.0. The minimal inhibitory concentrations of the extract against strains ranged 0.064-0.256mg/mL. Urushiol caused separation of the membrane and lysis of H. pylori within 10 minutes. Urushiol (0.128mg/mL×7days) did not cause complications on mice. The eradication rates were 33% in the urushiol monotherapy, 75% in the triple therapy (omeprazole+clarithromycin+metronidazole), and 100% in the urushiol+triple therapy, respectively. H. pylori-induced gastritis was not changed by urushiol but reduced by eradication. Only the expression of interleukin-1β in the gastric tissue was significantly increased by H. pylori infection and reduced by the urushiol and H. pylori eradication (p = .014). Conclusions: The urushiol has an antibacterial effect against H. pylori infection and can be used safely for H. pylori eradication in a mouse model.

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