Antibiotic-related adverse drug reactions at a tertiary care hospital in South Korea

In Young Jung, Jung Ju Kim, Se Ju Lee, Jinnam Kim, Hye Seong, Wooyong Jeong, Heun Choi, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, Jung Won Park, June Myung Kim

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Abstract

Background.Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects frommedication resulting in physical,mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods.This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results. 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%).Totally, 44 (3.4%) patients experienced seriousADRs. Penicillin and quinoloneswere themost common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%).The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion. Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.

Original languageEnglish
Article number4304973
JournalBioMed Research International
Volume2017
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Jung, I. Y., Kim, J. J., Lee, S. J., Kim, J., Seong, H., Jeong, W., Choi, H., Jeong, S. J., Ku, N. S., Han, S. H., Choi, J. Y., Song, Y. G., Park, J. W., & Kim, J. M. (2017). Antibiotic-related adverse drug reactions at a tertiary care hospital in South Korea. BioMed Research International, 2017, [4304973]. https://doi.org/10.1155/2017/4304973