Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Jaemoon Yang, Choong Hwan Lee, Joseph Park, Sungbaek Seo, Eun Kyung Lim, Yong Jin Song, Jinsuck Suh, Ho Geun Yoon, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

Original languageEnglish
Pages (from-to)2695-2699
Number of pages5
JournalJournal of Materials Chemistry
Volume17
Issue number26
DOIs
Publication statusPublished - 2007 Aug 2

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Antibodies
Nanoparticles
Magnetic resonance
Pharmaceutical Preparations
Nanocrystals
Cells
Imaging techniques
Kinetics
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

Cite this

Yang, Jaemoon ; Lee, Choong Hwan ; Park, Joseph ; Seo, Sungbaek ; Lim, Eun Kyung ; Song, Yong Jin ; Suh, Jinsuck ; Yoon, Ho Geun ; Huh, yongmin ; Haam, Seungjoo. / Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer. In: Journal of Materials Chemistry. 2007 ; Vol. 17, No. 26. pp. 2695-2699.
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Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer. / Yang, Jaemoon; Lee, Choong Hwan; Park, Joseph; Seo, Sungbaek; Lim, Eun Kyung; Song, Yong Jin; Suh, Jinsuck; Yoon, Ho Geun; Huh, yongmin; Haam, Seungjoo.

In: Journal of Materials Chemistry, Vol. 17, No. 26, 02.08.2007, p. 2695-2699.

Research output: Contribution to journalArticle

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