Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Jaemoon Yang; Choong Hwan Lee; Joseph Park; Sungbaek Seo; Eun Kyung Lim; Yong Jin Song; Jin Suck Suh; Ho Geun Yoon; Yong Min Huh; Seungjoo Haam

doi:10.1039/b702538f

Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Jaemoon Yang, Choong Hwan Lee, Joseph Park, Sungbaek Seo, Eun Kyung Lim, Yong Jin Song, Jin Suck Suh, Ho Geun Yoon, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

166 Citations (Scopus)

Abstract

DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

Original language	English
Pages (from-to)	2695-2699
Number of pages	5
Journal	Journal of Materials Chemistry
Volume	17
Issue number	26
DOIs	https://doi.org/10.1039/b702538f
Publication status	Published - 2007

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b702538f

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title = "Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer",

abstract = "DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.",

author = "Jaemoon Yang and Lee, {Choong Hwan} and Joseph Park and Sungbaek Seo and Lim, {Eun Kyung} and Song, {Yong Jin} and Suh, {Jin Suck} and Yoon, {Ho Geun} and Huh, {Yong Min} and Seungjoo Haam",

year = "2007",

doi = "10.1039/b702538f",

language = "English",

volume = "17",

pages = "2695--2699",

journal = "Journal of Materials Chemistry",

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TY - JOUR

T1 - Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

AU - Yang, Jaemoon

AU - Lee, Choong Hwan

AU - Park, Joseph

AU - Seo, Sungbaek

AU - Lim, Eun Kyung

AU - Song, Yong Jin

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2007

Y1 - 2007

N2 - DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

AB - DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

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U2 - 10.1039/b702538f

DO - 10.1039/b702538f

M3 - Article

AN - SCOPUS:34547257015

SN - 0959-9428

VL - 17

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EP - 2699

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 26

ER -

Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Abstract

All Science Journal Classification (ASJC) codes

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