Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Jaemoon Yang, Choong Hwan Lee, Joseph Park, Sungbaek Seo, Eun Kyung Lim, Yong Jin Song, Jin Suck Suh, Ho Geun Yoon, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

DOX-magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

Original languageEnglish
Pages (from-to)2695-2699
Number of pages5
JournalJournal of Materials Chemistry
Volume17
Issue number26
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

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