Anticancer drug-phospholipid conjugate for enhancement of intracellular drug delivery

Taewon Hwang, Hee Dong Han, Chung Kil Song, Hasoo Seong, Jung-Hyun Kim, Xiaoyuan Chen, Byung Cheol Shin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 9430505484, USA 10.1002/masy.200750318 Tumor specific delivery of anti-cancer drugs is one of the major challenges faced by drug development processes. In this study, we prepared a doxorubicin (DOX)-conjugated liposome (DCL) by incorporating the newly synthesized DSPE-PEG2000-DOX (DPD) into liposomes as a lipid component and tested its anti-tumor activity in vivo. DPD was synthesized by coupling DOX to DSPE-PEG2000-COOH via amide linkage and the chemical structure of resulting DPD was confirmed by 1H-NMR analysis. DCL having liposome size of 130 nm was prepared through thin film cast-hydration method. DCL was found to have significantly higher cellular uptake than conventional liposomes as confirmed by flow cytometry analysis. Anti-tumor activity of DCL against murine B16F10 melanoma tumor-bearing mice revealed that DCL inhibits tumor growth more efficiently than the conventional liposomes, presumably attributed to DOX mediated endocytosis process.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalMacromolecular Symposia
Volume249-250
DOIs
Publication statusPublished - 2007 Aug 1

Fingerprint

Liposomes
Phospholipids
Drug delivery
delivery
drugs
tumors
augmentation
Tumors
Pharmaceutical Preparations
Doxorubicin
university program
cytometry
radiology
medicine
linkages
amides
mice
Bearings (structural)
hydration
lipids

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Hwang, Taewon ; Han, Hee Dong ; Song, Chung Kil ; Seong, Hasoo ; Kim, Jung-Hyun ; Chen, Xiaoyuan ; Shin, Byung Cheol. / Anticancer drug-phospholipid conjugate for enhancement of intracellular drug delivery. In: Macromolecular Symposia. 2007 ; Vol. 249-250. pp. 109-115.
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Anticancer drug-phospholipid conjugate for enhancement of intracellular drug delivery. / Hwang, Taewon; Han, Hee Dong; Song, Chung Kil; Seong, Hasoo; Kim, Jung-Hyun; Chen, Xiaoyuan; Shin, Byung Cheol.

In: Macromolecular Symposia, Vol. 249-250, 01.08.2007, p. 109-115.

Research output: Contribution to journalArticle

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