Antifungal susceptibilities to amphotericin B, triazoles and echinocandins of 77 clinical isolates of cryptic Aspergillus species in multicenter surveillance in Korea

Eun Jeong Won, Jong Hee Shin, Soo Hyun Kim, Min Ji Choi, Seung A. Byun, Mi Na Kim, Wee Gyo Lee, Kyungwon Lee, Young Uh, Myung Geun Shin, Soon Pal Suh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We investigated the in vitro antifungal susceptibilities of cryptic Aspergillus species from nine Korean hospitals. Based on the CLSI epidemiological cutoff values, resistance rates to amphotericin B, itraconazole, voriconazole, posaconazole and caspofungin were as follows: A. awamori (34 isolates; all 0%), A. tubingensis (22; 0%, 4.5%, 0%, 0%, and 0%, respectively), A. sydowii (16; 0%, 6.3%, 0%, 0%, and 6.3%), A. lentulus (2; 50%, 0%, 100%, 50%, and 0%), and A. tamarii (2; all 0%). A. calidoustus (one isolate) showed resistance to multiple drugs. Thus, cryptic species identification can be mandatory for clinically important Aspergillus isolates, with their susceptibility data.

Original languageEnglish
Pages (from-to)501-505
Number of pages5
JournalMedical mycology
Volume56
Issue number4
DOIs
Publication statusPublished - 2018 Jun 1

Bibliographical note

Funding Information:
This research was supported by a fund (2015E4400100) by Research of Korea Centers for Disease Control and Prevention, and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2016R1A2B4008181; NRF- 2016R1C1B1009746).

Publisher Copyright:
© 2018 The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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