Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare

Eun Mi Choi; Jae Kwan Hwang

doi:10.1016/j.fitote.2004.05.005

Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare

Eun Mi Choi, Jae Kwan Hwang

Research output: Contribution to journal › Article › peer-review

207 Citations (Scopus)

Abstract

Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.

Original language	English
Pages (from-to)	557-565
Number of pages	9
Journal	Fitoterapia
Volume	75
Issue number	6
DOIs	https://doi.org/10.1016/j.fitote.2004.05.005
Publication status	Published - 2004 Sep

Bibliographical note

Funding Information:
The work was supported by the Korea Research Foundation Grant (KRF-2002-037-F00013).

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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title = "Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare",

abstract = "Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.",

author = "Choi, {Eun Mi} and Hwang, {Jae Kwan}",

note = "Funding Information: The work was supported by the Korea Research Foundation Grant (KRF-2002-037-F00013). ",

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AU - Choi, Eun Mi

AU - Hwang, Jae Kwan

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AB - Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.

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